Studio della funzionalità beta-pancreatica in pazienti adulti con deficit di GH.

A. Ardizzi; G. Guzzaloni; G. Grugni; G. Moreni; A. Sartorio; A. Conti; F. Morabito

Studio della funzionalità beta-pancreatica in pazienti adulti con deficit di GH.

Translated title of the contribution: Beta-pancreatic function in adult patients with GH deficiency

A. Ardizzi, G. Guzzaloni, G. Grugni, G. Moreni, A. Sartorio, A. Conti, F. Morabito

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.

Translated title of the contribution	Beta-pancreatic function in adult patients with GH deficiency
Original language	Italian
Pages (from-to)	105-109
Number of pages	5
Journal	Minerva Endocrinologica
Volume	15
Issue number	2
Publication status	Published - Apr 1990

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Studio della funzionalit{\`a} beta-pancreatica in pazienti adulti con deficit di GH.",

abstract = "We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.",

author = "A. Ardizzi and G. Guzzaloni and G. Grugni and G. Moreni and A. Sartorio and A. Conti and F. Morabito",

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AU - Ardizzi, A.

AU - Guzzaloni, G.

AU - Grugni, G.

AU - Moreni, G.

AU - Sartorio, A.

AU - Conti, A.

AU - Morabito, F.

PY - 1990/4

Y1 - 1990/4

N2 - We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.

AB - We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.

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Studio della funzionalità beta-pancreatica in pazienti adulti con deficit di GH.

Abstract

ASJC Scopus subject areas

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