Studio della funzionalità beta-pancreatica in pazienti adulti con deficit di GH.

Translated title of the contribution: Beta-pancreatic function in adult patients with GH deficiency

A. Ardizzi, G. Guzzaloni, G. Grugni, G. Moreni, A. Sartorio, A. Conti, F. Morabito

Research output: Contribution to journalArticle

Abstract

We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.

Original languageItalian
Pages (from-to)105-109
Number of pages5
JournalMinerva Endocrinologica
Volume15
Issue number2
Publication statusPublished - Apr 1990

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Tolbutamide
Glucose Tolerance Test
Insulin-Secreting Cells
Area Under Curve
Fasting
Insulin
Glucose
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

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Studio della funzionalità beta-pancreatica in pazienti adulti con deficit di GH. / Ardizzi, A.; Guzzaloni, G.; Grugni, G.; Moreni, G.; Sartorio, A.; Conti, A.; Morabito, F.

In: Minerva Endocrinologica, Vol. 15, No. 2, 04.1990, p. 105-109.

Research output: Contribution to journalArticle

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AU - Sartorio, A.

AU - Conti, A.

AU - Morabito, F.

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