Abstract
We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.
| Original language | Italian |
|---|---|
| Pages (from-to) | 105-109 |
| Number of pages | 5 |
| Journal | Minerva Endocrinologica |
| Volume | 15 |
| Issue number | 2 |
| Publication status | Published - Apr 1990 |
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Studio della funzionalità beta-pancreatica in pazienti adulti con deficit di GH. / Ardizzi, A.; Guzzaloni, G.; Grugni, G.; Moreni, G.; Sartorio, A.; Conti, A.; Morabito, F.
In: Minerva Endocrinologica, Vol. 15, No. 2, 04.1990, p. 105-109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Studio della funzionalità beta-pancreatica in pazienti adulti con deficit di GH.
AU - Ardizzi, A.
AU - Guzzaloni, G.
AU - Grugni, G.
AU - Moreni, G.
AU - Sartorio, A.
AU - Conti, A.
AU - Morabito, F.
PY - 1990/4
Y1 - 1990/4
N2 - We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.
AB - We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025406138&partnerID=8YFLogxK
M3 - Articolo
C2 - 2098650
AN - SCOPUS:0025406138
VL - 15
SP - 105
EP - 109
JO - Minerva Endocrinologica
JF - Minerva Endocrinologica
SN - 0391-1977
IS - 2
ER -