Beta-radiation therapy for long lesions in native coronary vessels - A matched comparison between de novo and in-stent restenotic lesions

Goran Stankovic, Dejan Orlic, Carlo Di Mario, Nicola Corvaja, Flavio Airoldi, Alaide Chieffo, Antonio Amato, Roberto Orecchia, Antonio Colombo

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of this study was to evaluate effectiveness and to compare clinical outcome of intracoronary beta-radiation to treat long lesions (>20 mm) in patients with de novo stenosis vs. patients with in-stent restenosis (ISR). Methods: A matched comparison of 44 patients with 63 de novo lesions and 48 patients with 63 ISR lesions (>20 mm) treated with intracoronary beta-radiation was performed. Results: Stents were implanted in 65.1% of de novo and 19% of ISR lesions (P=.001). Radiation doses delivered were 17.2±3.0 vs. 20.3±3.0 Gy at 2 mm from the source center for de novo and ISR lesions. There was no difference in the incidence of in-hospital events. Clinical follow-up at 16.4±6.7 months showed no difference in major adverse cardiac events (MACE) between de novo and ISR patients (27.3% vs. 25%, P=.8). Late total occlusions (LTOs) occurred in eight patients (four in each group) treated with stents at the time of radiation and after discontinuation of ticlopidine. By multivariate analysis, stent implantation was the only predictor of late occlusions (OR 8.25, 95% CI 1.73-38.46, P

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalCardiovascular Radiation Medicine
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2003

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Keywords

  • Antiplatelet therapy
  • Intracoronary radiation therapy
  • Restenosis
  • Stents

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Surgery

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