Better compliance to antihypertensive medications reduces cardiovascular risk

Giovanni Corrao, Andrea Parodi, Federica Nicotra, Antonella Zambon, Luca Merlino, Giancarlo Cesana, Giuseppe Mancia

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Objective: The effect of compliance with antihypertensive medications on the risk of cardiovascular outcomes in a population without a known history of cardiovascular disease has been addressed by a large population-based prospective, cohort study carried out by linking Italian administrative databases. Methods: The cohort of 242 594 patients aged 18 years or older, residents in the Italian Lombardy Region, who were newly treated for hypertension during 2000-2001, was followed from index prescription until 2007. During this period patients who experienced a hospitalization for coronary or cerebrovascular disease were identified (outcome). Exposure to antihypertensive drugs from index prescription until the date of hospitalization or censoring was assessed. Proportional hazards models were fitted to assess the association between persistence on and adherence with antihypertensive drug therapy and outcome. Data were adjusted for several covariates. Results: During an average follow-up of 6 years, 12 016 members of the cohort experienced the outcome. Compared with patients who experienced at least one episode of treatment discontinuation, those who continued treatment had a 37% reduced risk of cardiovascular outcomes (95% confidence interval 34-40%). Compared with patients who had very low drug coverage (proportion of days covered ≤25%), those at intermediate (from 51 to 75%) and high coverage (>75%) had risk reductions of 20% (16-24%) and 25% (20-29%), respectively. Similar effects were observed when coronary and cerebrovascular events were considered separately. Conclusions: In the real life setting, fulfillment compliance with antihypertensive medications is effective in the primary prevention of cardiovascular outcomes.

Original languageEnglish
Pages (from-to)610-618
Number of pages9
JournalJournal of Hypertension
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Antihypertensive Agents
Hospitalization
Cerebrovascular Disorders
Drug Prescriptions
Risk Reduction Behavior
Primary Prevention
Proportional Hazards Models
Population
Prescriptions
Coronary Disease
Cohort Studies
Cardiovascular Diseases
Databases
Prospective Studies
Confidence Intervals
Hypertension
Drug Therapy
Therapeutics
Pharmaceutical Preparations

Keywords

  • adherence
  • antihypertensive agents
  • cardiovascular disease
  • discontinuation
  • persistence
  • primary prevention

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Corrao, G., Parodi, A., Nicotra, F., Zambon, A., Merlino, L., Cesana, G., & Mancia, G. (2011). Better compliance to antihypertensive medications reduces cardiovascular risk. Journal of Hypertension, 29(3), 610-618. https://doi.org/10.1097/HJH.0b013e328342ca97

Better compliance to antihypertensive medications reduces cardiovascular risk. / Corrao, Giovanni; Parodi, Andrea; Nicotra, Federica; Zambon, Antonella; Merlino, Luca; Cesana, Giancarlo; Mancia, Giuseppe.

In: Journal of Hypertension, Vol. 29, No. 3, 03.2011, p. 610-618.

Research output: Contribution to journalArticle

Corrao, G, Parodi, A, Nicotra, F, Zambon, A, Merlino, L, Cesana, G & Mancia, G 2011, 'Better compliance to antihypertensive medications reduces cardiovascular risk', Journal of Hypertension, vol. 29, no. 3, pp. 610-618. https://doi.org/10.1097/HJH.0b013e328342ca97
Corrao G, Parodi A, Nicotra F, Zambon A, Merlino L, Cesana G et al. Better compliance to antihypertensive medications reduces cardiovascular risk. Journal of Hypertension. 2011 Mar;29(3):610-618. https://doi.org/10.1097/HJH.0b013e328342ca97
Corrao, Giovanni ; Parodi, Andrea ; Nicotra, Federica ; Zambon, Antonella ; Merlino, Luca ; Cesana, Giancarlo ; Mancia, Giuseppe. / Better compliance to antihypertensive medications reduces cardiovascular risk. In: Journal of Hypertension. 2011 ; Vol. 29, No. 3. pp. 610-618.
@article{0a6253a1cf7a4bb7bdd85bea828f938c,
title = "Better compliance to antihypertensive medications reduces cardiovascular risk",
abstract = "Objective: The effect of compliance with antihypertensive medications on the risk of cardiovascular outcomes in a population without a known history of cardiovascular disease has been addressed by a large population-based prospective, cohort study carried out by linking Italian administrative databases. Methods: The cohort of 242 594 patients aged 18 years or older, residents in the Italian Lombardy Region, who were newly treated for hypertension during 2000-2001, was followed from index prescription until 2007. During this period patients who experienced a hospitalization for coronary or cerebrovascular disease were identified (outcome). Exposure to antihypertensive drugs from index prescription until the date of hospitalization or censoring was assessed. Proportional hazards models were fitted to assess the association between persistence on and adherence with antihypertensive drug therapy and outcome. Data were adjusted for several covariates. Results: During an average follow-up of 6 years, 12 016 members of the cohort experienced the outcome. Compared with patients who experienced at least one episode of treatment discontinuation, those who continued treatment had a 37{\%} reduced risk of cardiovascular outcomes (95{\%} confidence interval 34-40{\%}). Compared with patients who had very low drug coverage (proportion of days covered ≤25{\%}), those at intermediate (from 51 to 75{\%}) and high coverage (>75{\%}) had risk reductions of 20{\%} (16-24{\%}) and 25{\%} (20-29{\%}), respectively. Similar effects were observed when coronary and cerebrovascular events were considered separately. Conclusions: In the real life setting, fulfillment compliance with antihypertensive medications is effective in the primary prevention of cardiovascular outcomes.",
keywords = "adherence, antihypertensive agents, cardiovascular disease, discontinuation, persistence, primary prevention",
author = "Giovanni Corrao and Andrea Parodi and Federica Nicotra and Antonella Zambon and Luca Merlino and Giancarlo Cesana and Giuseppe Mancia",
year = "2011",
month = "3",
doi = "10.1097/HJH.0b013e328342ca97",
language = "English",
volume = "29",
pages = "610--618",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Better compliance to antihypertensive medications reduces cardiovascular risk

AU - Corrao, Giovanni

AU - Parodi, Andrea

AU - Nicotra, Federica

AU - Zambon, Antonella

AU - Merlino, Luca

AU - Cesana, Giancarlo

AU - Mancia, Giuseppe

PY - 2011/3

Y1 - 2011/3

N2 - Objective: The effect of compliance with antihypertensive medications on the risk of cardiovascular outcomes in a population without a known history of cardiovascular disease has been addressed by a large population-based prospective, cohort study carried out by linking Italian administrative databases. Methods: The cohort of 242 594 patients aged 18 years or older, residents in the Italian Lombardy Region, who were newly treated for hypertension during 2000-2001, was followed from index prescription until 2007. During this period patients who experienced a hospitalization for coronary or cerebrovascular disease were identified (outcome). Exposure to antihypertensive drugs from index prescription until the date of hospitalization or censoring was assessed. Proportional hazards models were fitted to assess the association between persistence on and adherence with antihypertensive drug therapy and outcome. Data were adjusted for several covariates. Results: During an average follow-up of 6 years, 12 016 members of the cohort experienced the outcome. Compared with patients who experienced at least one episode of treatment discontinuation, those who continued treatment had a 37% reduced risk of cardiovascular outcomes (95% confidence interval 34-40%). Compared with patients who had very low drug coverage (proportion of days covered ≤25%), those at intermediate (from 51 to 75%) and high coverage (>75%) had risk reductions of 20% (16-24%) and 25% (20-29%), respectively. Similar effects were observed when coronary and cerebrovascular events were considered separately. Conclusions: In the real life setting, fulfillment compliance with antihypertensive medications is effective in the primary prevention of cardiovascular outcomes.

AB - Objective: The effect of compliance with antihypertensive medications on the risk of cardiovascular outcomes in a population without a known history of cardiovascular disease has been addressed by a large population-based prospective, cohort study carried out by linking Italian administrative databases. Methods: The cohort of 242 594 patients aged 18 years or older, residents in the Italian Lombardy Region, who were newly treated for hypertension during 2000-2001, was followed from index prescription until 2007. During this period patients who experienced a hospitalization for coronary or cerebrovascular disease were identified (outcome). Exposure to antihypertensive drugs from index prescription until the date of hospitalization or censoring was assessed. Proportional hazards models were fitted to assess the association between persistence on and adherence with antihypertensive drug therapy and outcome. Data were adjusted for several covariates. Results: During an average follow-up of 6 years, 12 016 members of the cohort experienced the outcome. Compared with patients who experienced at least one episode of treatment discontinuation, those who continued treatment had a 37% reduced risk of cardiovascular outcomes (95% confidence interval 34-40%). Compared with patients who had very low drug coverage (proportion of days covered ≤25%), those at intermediate (from 51 to 75%) and high coverage (>75%) had risk reductions of 20% (16-24%) and 25% (20-29%), respectively. Similar effects were observed when coronary and cerebrovascular events were considered separately. Conclusions: In the real life setting, fulfillment compliance with antihypertensive medications is effective in the primary prevention of cardiovascular outcomes.

KW - adherence

KW - antihypertensive agents

KW - cardiovascular disease

KW - discontinuation

KW - persistence

KW - primary prevention

UR - http://www.scopus.com/inward/record.url?scp=79951677672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951677672&partnerID=8YFLogxK

U2 - 10.1097/HJH.0b013e328342ca97

DO - 10.1097/HJH.0b013e328342ca97

M3 - Article

VL - 29

SP - 610

EP - 618

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 3

ER -