Bevacizumab and non-small-cell lung cancer: Starving the enemy to survive

Francesco Grossi, Marianna Aita

Research output: Contribution to journalArticle

Abstract

Although platinum-based chemotherapy remains a mainstay of non-small-cell lung cancer treatment, its efficacy has probably reached a plateau. Increased understanding of cancer biology has allowed the identification of a number of possible molecular targets, including the EGF receptor and the angiogenesis pathway. ECOG-E4599 has randomised chemonaive patients to receive paclitaxel - carboplatin with and without bevacizumab, a humanised monoclonal antibody targeting the VEGF. The study is the first to show a survival advantage of adding a biological agent to chemotherapy in this setting: in particular, for the first time the survival of lung cancer patients has been extended beyond 1 year. The aim of this review is to describe the biological and clinical properties of bevacizumab and to discuss the evidence that has supported its approval for the first-line treatment of advanced non-squamous non-small-cell lung cancer.

Original languageEnglish
Pages (from-to)1107-1119
Number of pages13
JournalExpert Opinion on Biological Therapy
Volume7
Issue number7
DOIs
Publication statusPublished - Jul 2007

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Keywords

  • Angiogenesis
  • Bevacizumab
  • Non-small-cell lung cancer
  • Targeted therapies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Immunology
  • Pharmacology

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