Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer: A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell'Italia Meridionale (GOIM 2802)

Evaristo Maiello; Gabriele Di Maggio; Stefano Cordio; Saverio Cinieri; Francesco Giuliani; Salvatore Pisconti; Antonio Rinaldi; Antonio Febbraro; Tiziana Pia Latiano; Michele Aieta; Antonio Rossi; Daniele Rizzi; Massimo Di Maio; Giuseppe Colucci; Roberto Bordonaro

doi:10.1016/j.clcc.2020.01.003

Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer: A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell'Italia Meridionale (GOIM 2802)

Evaristo Maiello, Gabriele Di Maggio, Stefano Cordio, Saverio Cinieri, Francesco Giuliani, Salvatore Pisconti, Antonio Rinaldi, Antonio Febbraro, Tiziana Pia Latiano, Michele Aieta, Antonio Rossi, Daniele Rizzi, Massimo Di Maio, Giuseppe Colucci, Roberto Bordonaro

Research output: Contribution to journal › Article › peer-review

Abstract

Bevacizumab plus either FOLFOX-4 (oxaliplatin, folinic acid, and infusional 5-fluorouracil) or XELOX-2 (capecitabine plus oxaliplatin) is among standard first-line treatment options in patients with metastatic colorectal cancer. This phase II randomized non-comparative trial evaluated the first-line combination of bevacizumab with either FOLFOX-4 or biweekly XELOX-2 in patients with metastatic colorectal cancer. Comparable response and a better tolerability for bevacizumab plus XELOX-2 was reported.

Original language	English
Pages (from-to)	109-115
Number of pages	7
Journal	Clinical Colorectal Cancer
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.clcc.2020.01.003
Publication status	Published - Jun 2020

Keywords

Capecitabine
Elderly
Fluoropyrimidine
Frail
Non-comparative

ASJC Scopus subject areas

Oncology
Gastroenterology

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Maiello, E., Di Maggio, G., Cordio, S., Cinieri, S., Giuliani, F., Pisconti, S., Rinaldi, A., Febbraro, A., Latiano, T. P., Aieta, M., Rossi, A., Rizzi, D., Di Maio, M., Colucci, G., & Bordonaro, R. (2020). Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer: A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell'Italia Meridionale (GOIM 2802). Clinical Colorectal Cancer, 19(2), 109-115. https://doi.org/10.1016/j.clcc.2020.01.003

Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer : A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell'Italia Meridionale (GOIM 2802). / Maiello, Evaristo; Di Maggio, Gabriele; Cordio, Stefano; Cinieri, Saverio; Giuliani, Francesco; Pisconti, Salvatore; Rinaldi, Antonio; Febbraro, Antonio; Latiano, Tiziana Pia ; Aieta, Michele; Rossi, Antonio; Rizzi, Daniele; Di Maio, Massimo; Colucci, Giuseppe; Bordonaro, Roberto.

In: Clinical Colorectal Cancer, Vol. 19, No. 2, 06.2020, p. 109-115.

Research output: Contribution to journal › Article › peer-review

Maiello, E, Di Maggio, G, Cordio, S, Cinieri, S, Giuliani, F, Pisconti, S, Rinaldi, A, Febbraro, A, Latiano, TP , Aieta, M, Rossi, A, Rizzi, D, Di Maio, M, Colucci, G & Bordonaro, R 2020, 'Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer: A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell'Italia Meridionale (GOIM 2802)', Clinical Colorectal Cancer, vol. 19, no. 2, pp. 109-115. https://doi.org/10.1016/j.clcc.2020.01.003

Maiello E, Di Maggio G, Cordio S, Cinieri S, Giuliani F, Pisconti S et al. Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer: A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell'Italia Meridionale (GOIM 2802). Clinical Colorectal Cancer. 2020 Jun;19(2):109-115. https://doi.org/10.1016/j.clcc.2020.01.003

Maiello, Evaristo ; Di Maggio, Gabriele ; Cordio, Stefano ; Cinieri, Saverio ; Giuliani, Francesco ; Pisconti, Salvatore ; Rinaldi, Antonio ; Febbraro, Antonio ; Latiano, Tiziana Pia ; Aieta, Michele ; Rossi, Antonio ; Rizzi, Daniele ; Di Maio, Massimo ; Colucci, Giuseppe ; Bordonaro, Roberto. / Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer : A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell'Italia Meridionale (GOIM 2802). In: Clinical Colorectal Cancer. 2020 ; Vol. 19, No. 2. pp. 109-115.

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Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer: A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell'Italia Meridionale (GOIM 2802)

Abstract

Keywords

ASJC Scopus subject areas

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