Bevacizumab in ovarian cancer: A critical review of phase III studies

Luigi Rossi, Monica Verrico, Eleonora Zaccarelli, Anselmo Papa, Maria Colonna, Martina Strudel, Patrizia Vici, Vincenzo Bianco, Federica Tomao

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Abstract

Bevacizumab (BV) is a humanized monoclonal antibody targeting vascular endothelial growth factor and it is the first molecular-targeted agent to be used for the treatment of ovarian cancer (OC). Randomized Phase III trials evaluated the combination of BV plus standard chemotherapy for first-line treatment of advanced OC and for platinum-sensitive and platinum-resistant recurrent OC. These trials reported a statistically significant improvement in progression-free survival but not in overall survival. Furthermore, BV effectively improved the quality of life with regard to abdominal symptoms in recurrent OC patients. Bevacizumab is associated with adverse events such as hypertension, bleeding, thromboembolism, proteinuria, delayed wound healing, and gastrointestinal events. However, most of these events can be adequately managed. This review describes the latest evidence for BV treatment of OC and selection of patients for personalized treatment.

Original languageEnglish
JournalOncotarget
DOIs
Publication statusE-pub ahead of print - Nov 11 2016

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Keywords

  • Review
  • Journal Article

Cite this

Rossi, L., Verrico, M., Zaccarelli, E., Papa, A., Colonna, M., Strudel, M., Vici, P., Bianco, V., & Tomao, F. (2016). Bevacizumab in ovarian cancer: A critical review of phase III studies. Oncotarget. https://doi.org/10.18632/oncotarget.13310