Bevacizumab treatment for advanced breast cancer

Ricardo H. Alvarez, Valentina Guarneri, Fikri Icli, Stephen Johnston, David Khayat, Sibylle Loibl, Miguel Martin, Christoph Zielinski, Pierfranco Conte, Gabriel N. Hortobagyi

Research output: Contribution to journalArticle

Abstract

Significant advances in the treatment of patients with breast cancer have been made in the past 10 years. The current systemic treatment of breast cancer is characterized by the discovery of multiple cancer targets leading to treatments that are more sophisticated and specific than conventional cytotoxic chemotherapy. Two classes of compounds that have helped improve clinical outcomes are small molecules and monoclonal antibodies targeting specific tyrosine kinase receptors. Many novel targets have been discovered, and parallel multiple approaches to anticancer therapy have recently emerged from the literature. One promising strategy is targeting the proangiogenic vascular endothelial growth factors (VEGFs), either by ligand sequestration (preventing VEGF receptor binding) or inhibiting downstream receptor signaling. Bevacizumab, a monoclonal antibody directed against VEGF, has been shown to improve the efficacy of taxanes in frontline treatment of patients with metastatic breast cancer. This review outlines the most promising breast cancer studies using bevacizumab combined with traditional cytotoxic agents in advanced breast cancer. In addition, we discuss the current indications reviewed by the Oncologic Drug Advisory Committee and define our vision of how the benefit of patient clinical trials should be measured.

Original languageEnglish
Pages (from-to)1684-1697
Number of pages14
JournalThe oncologist
Volume16
Issue number12
DOIs
Publication statusPublished - 2011

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Keywords

  • Advanced breast cancer
  • Antiangiogenesis
  • Bevacizumab
  • FDA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Alvarez, R. H., Guarneri, V., Icli, F., Johnston, S., Khayat, D., Loibl, S., Martin, M., Zielinski, C., Conte, P., & Hortobagyi, G. N. (2011). Bevacizumab treatment for advanced breast cancer. The oncologist, 16(12), 1684-1697. https://doi.org/10.1634/theoncologist.2011-0113