Abstract
Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as preliminary. Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.
| Original language | English |
|---|---|
| Pages (from-to) | 238-246 |
| Number of pages | 9 |
| Journal | International Journal of Technology Assessment in Health Care |
| Volume | 12 |
| Issue number | 2 |
| Publication status | Published - Mar 1996 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Health Informatics
- Health Information Management
- Nursing(all)
Cite this
Beware of surrogate outcome measures. / Gøtzsche, Peter C.; Liberati, Alessandro; Torri, Valter; Rossetti, Luca.
In: International Journal of Technology Assessment in Health Care, Vol. 12, No. 2, 03.1996, p. 238-246.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Beware of surrogate outcome measures
AU - Gøtzsche, Peter C.
AU - Liberati, Alessandro
AU - Torri, Valter
AU - Rossetti, Luca
PY - 1996/3
Y1 - 1996/3
N2 - Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as preliminary. Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.
AB - Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as preliminary. Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.
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M3 - Article
C2 - 8707497
AN - SCOPUS:0030013022
VL - 12
SP - 238
EP - 246
JO - International Journal of Technology Assessment in Health Care
JF - International Journal of Technology Assessment in Health Care
SN - 0266-4623
IS - 2
ER -