Beware of surrogate outcome measures

Peter C. Gøtzsche; Alessandro Liberati; Valter Torri; Luca Rossetti

Beware of surrogate outcome measures

Peter C. Gøtzsche, Alessandro Liberati, Valter Torri, Luca Rossetti

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as preliminary. Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.

Original language	English
Pages (from-to)	238-246
Number of pages	9
Journal	International Journal of Technology Assessment in Health Care
Volume	12
Issue number	2
Publication status	Published - Mar 1996

ASJC Scopus subject areas

Medicine (miscellaneous)
Health Informatics
Health Information Management
Nursing(all)

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title = "Beware of surrogate outcome measures",

abstract = "Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as preliminary. Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.",

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