Beyond appearance: An unusual manifestation of isolated oral secondary syphilis

Elena Mari, Maurizio Nudo, Enzo Palese, Luisa Cotticelli, Ciro Cotticelli, Grazia Zino, Rosa Coppola, Federica Maria Di Lella, Gabriele Arcari, Donatella Maria Rodio, Carla Prezioso, Valeria Pietropaolo, Valeria Devirgiliis, Vincenzo Panasiti

Research output: Contribution to journalArticlepeer-review


Syphilis is a sexually acquired chronic infection caused by Treponema pallidum and is characterized by a variety of clinical manifestations. The secondary stage of the disease results from the hematogenous and lymphatic dissemination of treponemes after a few weeks or months, and it is characterized by recurrent activity of the disease, with muco-cutaneous as well as systemic manifestations. Mucosal lesions range from small, superficial ulcers that resemble painless aphthae to large gray plaques, and they are generally associated with systemic manifestations of the disease. The exclusive asymptomatic oral localization not associated with general manifestations is uncommon but may actually be unrecognized and under-reported. We report a case of isolated oral manifestation as the unique presentation of secondary syphilis.

Original languageEnglish
Pages (from-to)2058738419845566
JournalInt. J. Immunopathol. Pharmacol.
Publication statusPublished - Apr 26 2019


  • Anti-Bacterial Agents/therapeutic use
  • Female
  • Humans
  • Middle Aged
  • Penicillin G Benzathine/therapeutic use
  • Syphilis/diagnosis


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