Beyond episodic memory: Semantic processing as independent predictor of hippocampal/perirhinal volume in aging and mild cognitive impairment due to Alzheimer's disease

Annalena Venneri, Micaela Mitolo, Leandro Beltrachini, Susheel Varma, Camilla Della Pietà, Caroline Jahn-Carta, Alejandro F Frangi, Matteo De Marco

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Given that lexical-semantic decline precedes episodic memory deficits in the Alzheimer's disease (AD) timeline, it is expected that performance on a lexical-semantic task would be associated with mediotemporal volumes independently of the association this region has with episodic memory in the early stage of AD.

METHOD: Fifty patients with mild cognitive impairment due to AD and 50 healthy adults completed tests of lexical-semantic skills (category fluency test), episodic memory for semantically relevant material (prose memory test), episodic memory for non semantically relevant material (Rey-Osterrieth Figure test), lexical-executive abilities (letter fluency test), and a neurostructural MRI. Hippocampal, perirhinal, entorhinal, temporopolar, and orbitofrontal volumes were extracted. The association between test performance and volume of each region was tested using partial correlations (age-education corrected). The improvement (ΔR2) in predicting volumetric indices offered by episodic-memory/lexical-semantic processing, once accounting for their counterpart, was tested using hierarchical regressions.

RESULTS: There were no significant findings for control indices. Prose memory accounted for independent portions of volumetric variability within almost all regions. Category fluency accounted for independent portions of volumetric variability of left and right hippocampus and left perirhinal cortex in addition to the predictive strength of the Rey-Osterrieth Figure, and for an independent portion of volumetric variability in the left hippocampus in addition to the predictive strength of prose memory.

CONCLUSIONS: There was an association between hippocampal and perirhinal volume and lexical-semantic processing in addition to the contribution given by episodic memory. This statistical separation supports the importance of lexical-semantic processing as independent indicator of AD. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Original languageEnglish
Pages (from-to)523-533
Number of pages11
JournalNeuropsychology
Volume33
Issue number4
DOIs
Publication statusPublished - May 2019

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Episodic Memory
Semantics
Alzheimer Disease
Hippocampus
Aptitude
Memory Disorders
Cognitive Dysfunction
Education

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Beyond episodic memory : Semantic processing as independent predictor of hippocampal/perirhinal volume in aging and mild cognitive impairment due to Alzheimer's disease. / Venneri, Annalena; Mitolo, Micaela; Beltrachini, Leandro; Varma, Susheel; Della Pietà, Camilla; Jahn-Carta, Caroline; Frangi, Alejandro F; De Marco, Matteo.

In: Neuropsychology, Vol. 33, No. 4, 05.2019, p. 523-533.

Research output: Contribution to journalArticle

Venneri, A, Mitolo, M, Beltrachini, L, Varma, S, Della Pietà, C, Jahn-Carta, C, Frangi, AF & De Marco, M 2019, 'Beyond episodic memory: Semantic processing as independent predictor of hippocampal/perirhinal volume in aging and mild cognitive impairment due to Alzheimer's disease', Neuropsychology, vol. 33, no. 4, pp. 523-533. https://doi.org/10.1037/neu0000534
Venneri, Annalena ; Mitolo, Micaela ; Beltrachini, Leandro ; Varma, Susheel ; Della Pietà, Camilla ; Jahn-Carta, Caroline ; Frangi, Alejandro F ; De Marco, Matteo. / Beyond episodic memory : Semantic processing as independent predictor of hippocampal/perirhinal volume in aging and mild cognitive impairment due to Alzheimer's disease. In: Neuropsychology. 2019 ; Vol. 33, No. 4. pp. 523-533.
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AU - Beltrachini, Leandro

AU - Varma, Susheel

AU - Della Pietà, Camilla

AU - Jahn-Carta, Caroline

AU - Frangi, Alejandro F

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N2 - OBJECTIVE: Given that lexical-semantic decline precedes episodic memory deficits in the Alzheimer's disease (AD) timeline, it is expected that performance on a lexical-semantic task would be associated with mediotemporal volumes independently of the association this region has with episodic memory in the early stage of AD.METHOD: Fifty patients with mild cognitive impairment due to AD and 50 healthy adults completed tests of lexical-semantic skills (category fluency test), episodic memory for semantically relevant material (prose memory test), episodic memory for non semantically relevant material (Rey-Osterrieth Figure test), lexical-executive abilities (letter fluency test), and a neurostructural MRI. Hippocampal, perirhinal, entorhinal, temporopolar, and orbitofrontal volumes were extracted. The association between test performance and volume of each region was tested using partial correlations (age-education corrected). The improvement (ΔR2) in predicting volumetric indices offered by episodic-memory/lexical-semantic processing, once accounting for their counterpart, was tested using hierarchical regressions.RESULTS: There were no significant findings for control indices. Prose memory accounted for independent portions of volumetric variability within almost all regions. Category fluency accounted for independent portions of volumetric variability of left and right hippocampus and left perirhinal cortex in addition to the predictive strength of the Rey-Osterrieth Figure, and for an independent portion of volumetric variability in the left hippocampus in addition to the predictive strength of prose memory.CONCLUSIONS: There was an association between hippocampal and perirhinal volume and lexical-semantic processing in addition to the contribution given by episodic memory. This statistical separation supports the importance of lexical-semantic processing as independent indicator of AD. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

AB - OBJECTIVE: Given that lexical-semantic decline precedes episodic memory deficits in the Alzheimer's disease (AD) timeline, it is expected that performance on a lexical-semantic task would be associated with mediotemporal volumes independently of the association this region has with episodic memory in the early stage of AD.METHOD: Fifty patients with mild cognitive impairment due to AD and 50 healthy adults completed tests of lexical-semantic skills (category fluency test), episodic memory for semantically relevant material (prose memory test), episodic memory for non semantically relevant material (Rey-Osterrieth Figure test), lexical-executive abilities (letter fluency test), and a neurostructural MRI. Hippocampal, perirhinal, entorhinal, temporopolar, and orbitofrontal volumes were extracted. The association between test performance and volume of each region was tested using partial correlations (age-education corrected). The improvement (ΔR2) in predicting volumetric indices offered by episodic-memory/lexical-semantic processing, once accounting for their counterpart, was tested using hierarchical regressions.RESULTS: There were no significant findings for control indices. Prose memory accounted for independent portions of volumetric variability within almost all regions. Category fluency accounted for independent portions of volumetric variability of left and right hippocampus and left perirhinal cortex in addition to the predictive strength of the Rey-Osterrieth Figure, and for an independent portion of volumetric variability in the left hippocampus in addition to the predictive strength of prose memory.CONCLUSIONS: There was an association between hippocampal and perirhinal volume and lexical-semantic processing in addition to the contribution given by episodic memory. This statistical separation supports the importance of lexical-semantic processing as independent indicator of AD. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

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SN - 0894-4105

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