Beyond head and neck cancer: The relationship between oral microbiota and tumour development in distant organs

Marco Mascitti, Lucrezia Togni, Giuseppe Troiano, Vito Carlo Alberto Caponio, Davide Bartolomeo Gissi, Lucio Montebugnoli, Maurizio Procaccini, Lorenzo Lo Muzio, Andrea Santarelli

Research output: Contribution to journalReview article

Abstract

An altered oral microbiota has been linked with the development of several oral diseases, such as dental caries, periodontal disease, and oral stomatitis. Moreover, poor oral health has been linked to head and neck cancer, particularly oral cancer. In recent years a growing number of studies indicate that oral microbiota could be involved in the development of primary tumours outside of head and neck region. The aim of this article is to review the recent studies based on high-throughput technology to present evidences of a relationship between oral microbiota and “non-head and neck tumours.” Oral dysbiosis seem to be more pronounced in patients with tumours of gastrointestinal tract, in particular oesophageal, gastric, pancreatic, and colorectal cancers, paving the way for developing specific oral microbiota test to allow early cancer detection. Regarding other tumour types, the results are promising but highly preliminary and still debated. Currently, there are several factors that limit the generalization of the results, such as the small sample size, the lack of adequate clinical information about patients, the different sequencing techniques used, and biological sample heterogeneity. Although only at the beginning, the analysis of oral microbiota could be the next step in the evolution of cancer therapy and will help clinicians to develop individualised approaches to cancer prevention and treatment.

Original languageEnglish
Article number232
JournalFrontiers in cellular and infection microbiology
Volume9
Issue numberJUN
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Gastrointestinal tract cancer
  • High-throughput sequencing
  • Oral microbiome
  • Oral microbiota
  • Pancreatic cancer

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    Mascitti, M., Togni, L., Troiano, G., Caponio, V. C. A., Gissi, D. B., Montebugnoli, L., Procaccini, M., Muzio, L. L., & Santarelli, A. (2019). Beyond head and neck cancer: The relationship between oral microbiota and tumour development in distant organs. Frontiers in cellular and infection microbiology, 9(JUN), [232]. https://doi.org/10.3389/fcimb.2019.00232