Beyond multidrug-resistant tuberculosis in Europe: A TBNET study

G. Günther, F. Van Leth, N. Altet, M. Dedicoat, R. Duarte, G. Gualano, H. Kunst, I. Muylle, V. Spinu, S. Tiberi, P. Viiklepp, C. Lange

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe.We evaluated secondline drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrugresistant, pre-extensively drug-resistant (pre-XDR-TB) and XDR-TB at 23 TBNET sites in 16 European countries. Over 30% of bacilli from patients with pre-XDR-TB showed resistance to any fluoroquinolone and almost 70% to any second-line injectable drug. Respectively >90% and >80% of the XDR-TB strains tested showed phenotypic resistance to pyrazinamide and ethambutol. Resistance to prothionamide/ethionamide was high in bacilli from pre-XDR-TB patients (43%) and XDR-TB patients (49%).

Original languageEnglish
Pages (from-to)1524-1527
Number of pages4
JournalInternational Journal of Tuberculosis and Lung Disease
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Multidrug-Resistant Tuberculosis
Tuberculosis
Bacillus
Prothionamide
Ethionamide
Pharmaceutical Preparations
Pyrazinamide
Ethambutol
Fluoroquinolones
Mycobacterium tuberculosis
Injections

Keywords

  • Drug resistance
  • Europe
  • Extensively drug-resistant tuberculosis
  • MDR-TB
  • TB
  • Tuberculosis Network European Trials

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Beyond multidrug-resistant tuberculosis in Europe : A TBNET study. / Günther, G.; Van Leth, F.; Altet, N.; Dedicoat, M.; Duarte, R.; Gualano, G.; Kunst, H.; Muylle, I.; Spinu, V.; Tiberi, S.; Viiklepp, P.; Lange, C.

In: International Journal of Tuberculosis and Lung Disease, Vol. 19, No. 12, 01.12.2015, p. 1524-1527.

Research output: Contribution to journalArticle

Günther, G, Van Leth, F, Altet, N, Dedicoat, M, Duarte, R, Gualano, G, Kunst, H, Muylle, I, Spinu, V, Tiberi, S, Viiklepp, P & Lange, C 2015, 'Beyond multidrug-resistant tuberculosis in Europe: A TBNET study', International Journal of Tuberculosis and Lung Disease, vol. 19, no. 12, pp. 1524-1527. https://doi.org/10.5588/ijtld.15.0274
Günther, G. ; Van Leth, F. ; Altet, N. ; Dedicoat, M. ; Duarte, R. ; Gualano, G. ; Kunst, H. ; Muylle, I. ; Spinu, V. ; Tiberi, S. ; Viiklepp, P. ; Lange, C. / Beyond multidrug-resistant tuberculosis in Europe : A TBNET study. In: International Journal of Tuberculosis and Lung Disease. 2015 ; Vol. 19, No. 12. pp. 1524-1527.
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