Abstract
The findings for implicit (procedural) learning impairment in major depression are mixed. We investigated this issue using transcranial direct current stimulation (tDCS), a method that non-invasively increases/decreases cortical activity. Twenty-eight age- and gender-matched, antidepressant-free depressed subjects received a single-session of active/sham tDCS. We used a bifrontal setup - anode and cathode over the left and the right dorsolateral prefrontal cortex (DLPFC), respectively. The probabilistic classification-learning (PCL) task was administered before and during tDCS. The percentage of correct responses improved during sham; although not during active tDCS. Procedural or implicit learning acquisition between tasks also occurred only for sham. We discuss whether DLPFC activation decreased activity in subcortical structures due to the depressive state. The deactivation of the right DLPFC by cathodal tDCS can also account for our results. To conclude, active bifrontal tDCS prevented implicit learning in depressive patients. Further studies with different tDCS montages and in other samples are necessary.
| Original language | English |
|---|---|
| Pages (from-to) | 146-150 |
| Number of pages | 5 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Volume | 43 |
| DOIs | |
| Publication status | Published - Jun 3 2013 |
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Keywords
- Implicit memory
- Major depressive disorder
- Probabilistic classification learning
- Procedural learning
- Transcranial direct current stimulation
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology
Cite this
Bifrontal tDCS prevents implicit learning acquisition in antidepressant-free patients with major depressive disorder. / Brunoni, Andre Russowsky; Zanao, Tamires Araujo; Ferrucci, Roberta; Priori, Alberto; Valiengo, Leandro; de Oliveira, Janaina Farias; Boggio, Paulo S.; Lotufo, Paulo A.; Benseñor, Isabela M.; Fregni, Felipe.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 43, 03.06.2013, p. 146-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bifrontal tDCS prevents implicit learning acquisition in antidepressant-free patients with major depressive disorder
AU - Brunoni, Andre Russowsky
AU - Zanao, Tamires Araujo
AU - Ferrucci, Roberta
AU - Priori, Alberto
AU - Valiengo, Leandro
AU - de Oliveira, Janaina Farias
AU - Boggio, Paulo S.
AU - Lotufo, Paulo A.
AU - Benseñor, Isabela M.
AU - Fregni, Felipe
PY - 2013/6/3
Y1 - 2013/6/3
N2 - The findings for implicit (procedural) learning impairment in major depression are mixed. We investigated this issue using transcranial direct current stimulation (tDCS), a method that non-invasively increases/decreases cortical activity. Twenty-eight age- and gender-matched, antidepressant-free depressed subjects received a single-session of active/sham tDCS. We used a bifrontal setup - anode and cathode over the left and the right dorsolateral prefrontal cortex (DLPFC), respectively. The probabilistic classification-learning (PCL) task was administered before and during tDCS. The percentage of correct responses improved during sham; although not during active tDCS. Procedural or implicit learning acquisition between tasks also occurred only for sham. We discuss whether DLPFC activation decreased activity in subcortical structures due to the depressive state. The deactivation of the right DLPFC by cathodal tDCS can also account for our results. To conclude, active bifrontal tDCS prevented implicit learning in depressive patients. Further studies with different tDCS montages and in other samples are necessary.
AB - The findings for implicit (procedural) learning impairment in major depression are mixed. We investigated this issue using transcranial direct current stimulation (tDCS), a method that non-invasively increases/decreases cortical activity. Twenty-eight age- and gender-matched, antidepressant-free depressed subjects received a single-session of active/sham tDCS. We used a bifrontal setup - anode and cathode over the left and the right dorsolateral prefrontal cortex (DLPFC), respectively. The probabilistic classification-learning (PCL) task was administered before and during tDCS. The percentage of correct responses improved during sham; although not during active tDCS. Procedural or implicit learning acquisition between tasks also occurred only for sham. We discuss whether DLPFC activation decreased activity in subcortical structures due to the depressive state. The deactivation of the right DLPFC by cathodal tDCS can also account for our results. To conclude, active bifrontal tDCS prevented implicit learning in depressive patients. Further studies with different tDCS montages and in other samples are necessary.
KW - Implicit memory
KW - Major depressive disorder
KW - Probabilistic classification learning
KW - Procedural learning
KW - Transcranial direct current stimulation
UR - http://www.scopus.com/inward/record.url?scp=84872507236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872507236&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2012.12.019
DO - 10.1016/j.pnpbp.2012.12.019
M3 - Article
C2 - 23274503
AN - SCOPUS:84872507236
VL - 43
SP - 146
EP - 150
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
ER -