TY - JOUR
T1 - Bilateral Acute Retinal Necrosis
T2 - Clinical Features and Outcomes in a Multicenter Study
AU - Miserocchi, Elisabetta
AU - Iuliano, Lorenzo
AU - Fogliato, Giovanni
AU - Modorati, Giulio
AU - Couto, Cristobal
AU - Schlaen, Ariel
AU - Hurtado, Erika
AU - Llorenç, Victor
AU - Adan, Alfredo
AU - Bandello, Francesco
PY - 2019/10/3
Y1 - 2019/10/3
N2 - Purpose: To describe clinical features and outcome in bilateral acute retinal necrosis (BARN). Methods: Observational retrospective longitudinal review of ocular findings. Results: Thirty eyes of 15 patients (age 44.1 ± 15.8). Delay of involvement between eyes was 57.2 ± 105.2 months (median 3, range 0.5–360). Herpes simplex virus (HSV)-1 was the most frequent (20 eyes, 66.6%), followed by HSV-2 (five eyes, 16.7%) and varicella zoster virus (VZV, four eyes, 13.3%). Visual acuity worsened in 7 (23%) eyes, improved in 4 (13%), and remained stable in 19 (63%). Major complications included retinal detachment (11 eyes, 36%), optic atrophy (11 eyes, 33%), proliferative vitreoretinopathy (four eyes, 13.3%), neovascular glaucoma (four eyes, 13.3%), phthisis bulbi (three eyes, 10%). Symptoms-to-referral average time was 2.7 ± 1.0 weeks (range 1–4). Conclusions: In our study BARN was associated with severe visual outcome and high rate of ocular complications. Although BARN is a rare disease, the course is aggressive, regardless prompt referral in tertiary-care uveitis centers.
AB - Purpose: To describe clinical features and outcome in bilateral acute retinal necrosis (BARN). Methods: Observational retrospective longitudinal review of ocular findings. Results: Thirty eyes of 15 patients (age 44.1 ± 15.8). Delay of involvement between eyes was 57.2 ± 105.2 months (median 3, range 0.5–360). Herpes simplex virus (HSV)-1 was the most frequent (20 eyes, 66.6%), followed by HSV-2 (five eyes, 16.7%) and varicella zoster virus (VZV, four eyes, 13.3%). Visual acuity worsened in 7 (23%) eyes, improved in 4 (13%), and remained stable in 19 (63%). Major complications included retinal detachment (11 eyes, 36%), optic atrophy (11 eyes, 33%), proliferative vitreoretinopathy (four eyes, 13.3%), neovascular glaucoma (four eyes, 13.3%), phthisis bulbi (three eyes, 10%). Symptoms-to-referral average time was 2.7 ± 1.0 weeks (range 1–4). Conclusions: In our study BARN was associated with severe visual outcome and high rate of ocular complications. Although BARN is a rare disease, the course is aggressive, regardless prompt referral in tertiary-care uveitis centers.
KW - Acute retinal necrosis
KW - bilateral acute retinal necrosis
KW - herpetic eye disease
KW - retina
KW - uveitis
UR - http://www.scopus.com/inward/record.url?scp=85051976584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051976584&partnerID=8YFLogxK
U2 - 10.1080/09273948.2018.1501494
DO - 10.1080/09273948.2018.1501494
M3 - Article
C2 - 30059636
AN - SCOPUS:85051976584
VL - 27
SP - 1090
EP - 1098
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
SN - 0927-3948
IS - 7
ER -