Bilateral Acute Retinal Necrosis: Clinical Features and Outcomes in a Multicenter Study

Elisabetta Miserocchi, Lorenzo Iuliano, Giovanni Fogliato, Giulio Modorati, Cristobal Couto, Ariel Schlaen, Erika Hurtado, Victor Llorenç, Alfredo Adan, Francesco Bandello

Research output: Contribution to journalArticlepeer-review


Purpose: To describe clinical features and outcome in bilateral acute retinal necrosis (BARN). Methods: Observational retrospective longitudinal review of ocular findings. Results: Thirty eyes of 15 patients (age 44.1 ± 15.8). Delay of involvement between eyes was 57.2 ± 105.2 months (median 3, range 0.5–360). Herpes simplex virus (HSV)-1 was the most frequent (20 eyes, 66.6%), followed by HSV-2 (five eyes, 16.7%) and varicella zoster virus (VZV, four eyes, 13.3%). Visual acuity worsened in 7 (23%) eyes, improved in 4 (13%), and remained stable in 19 (63%). Major complications included retinal detachment (11 eyes, 36%), optic atrophy (11 eyes, 33%), proliferative vitreoretinopathy (four eyes, 13.3%), neovascular glaucoma (four eyes, 13.3%), phthisis bulbi (three eyes, 10%). Symptoms-to-referral average time was 2.7 ± 1.0 weeks (range 1–4). Conclusions: In our study BARN was associated with severe visual outcome and high rate of ocular complications. Although BARN is a rare disease, the course is aggressive, regardless prompt referral in tertiary-care uveitis centers.

Original languageEnglish
Pages (from-to)1090-1098
Number of pages9
JournalOcular Immunology and Inflammation
Issue number7
Publication statusPublished - Oct 3 2019


  • Acute retinal necrosis
  • bilateral acute retinal necrosis
  • herpetic eye disease
  • retina
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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