TY - JOUR
T1 - Bilateral breast metastases from epstein-barr virus-associated gastric cancer during pregnancy:
T2 - Is there a method to its madness?
AU - Quaquarini, E.
AU - Vanoli, A.
AU - Frascaroli, M.
AU - Viglio, A.
AU - Lucioni, M.
AU - Presti, D.
AU - Lobascio, G.
AU - Pietrabissa, A.
AU - Bernardo, A.
AU - Paulli, M.
N1 - Export Date: 28 December 2020
PY - 2020
Y1 - 2020
N2 - Breast metastases of extramammary malignant neoplasms are rare, with an incidence of 0.3%–2.7% among all malignant mammary tumors. Breast metastases from gastric carcinoma are very rare (<0.1%), and this event is even rarer during pregnancy. Herein, we describe a 39-year-old Caucasian woman with a history of an Epstein-Barr virus-associated gastric carcinoma (EBVaGC) that was characterized by prominent tumor infiltrating lymphocytes. Three years after undergoing radical surgery, the patient developed bilateral breast nodules during her pregnancy. A breast biopsy was performed, and histology confirmed a diagnosis of EBVaGC; tumor cells showed positivity for cytokeratin 8/18 and E-cadherin, and negativity for cytokeratin 7, cytokeratin 20, cytokeratin 5/6, caudal type homebox 2, androgen receptor, mammaglobin, gross cystic disease fluid protein-15, and estrogen and progesterone receptors. We also discuss the main diagnostic pitfalls. To our knowledge, this is the first report of an EBVaGC with lymphoid stroma that developed breasmetastases during pregnancy. © 2020. Korean Gastric Cancer Association.
AB - Breast metastases of extramammary malignant neoplasms are rare, with an incidence of 0.3%–2.7% among all malignant mammary tumors. Breast metastases from gastric carcinoma are very rare (<0.1%), and this event is even rarer during pregnancy. Herein, we describe a 39-year-old Caucasian woman with a history of an Epstein-Barr virus-associated gastric carcinoma (EBVaGC) that was characterized by prominent tumor infiltrating lymphocytes. Three years after undergoing radical surgery, the patient developed bilateral breast nodules during her pregnancy. A breast biopsy was performed, and histology confirmed a diagnosis of EBVaGC; tumor cells showed positivity for cytokeratin 8/18 and E-cadherin, and negativity for cytokeratin 7, cytokeratin 20, cytokeratin 5/6, caudal type homebox 2, androgen receptor, mammaglobin, gross cystic disease fluid protein-15, and estrogen and progesterone receptors. We also discuss the main diagnostic pitfalls. To our knowledge, this is the first report of an EBVaGC with lymphoid stroma that developed breasmetastases during pregnancy. © 2020. Korean Gastric Cancer Association.
U2 - 10.5230/jgc.2020.20.e1
DO - 10.5230/jgc.2020.20.e1
M3 - Article
VL - 20
SP - 106
EP - 114
JO - Journal of Gastric Cancer
JF - Journal of Gastric Cancer
SN - 2093-582X
IS - 1
ER -