Bilateral cavitations of ganglionic eminence: A fetal MR imaging sign of halted brain development

A. Righini, C. Frassoni, F. Inverardi, C. Parazzini, D. Mei, C. Doneda, T. J. Re, I. Zucca, R. Guerrini, R. Spreafico, F. Triulzi

Research output: Contribution to journalArticlepeer-review

Abstract

Ganglionic eminence is the main transitory proliferative structure of the ventral telencephalon in human fetal brain and it contributes for at least 35% to the population of cortical interneurons; however data on the human GE anomalies are scarce. We report 5 fetal MR imaging observations with bilateral symmetric cavitations in their GE regions resembling an inverted open C shape and separating the GE itself form the deeper parenchyma. Imaging, neuropathology, and follow-up features suggested a malformative origin. All cases had in common characteristics of lissencephaly with agenesis or severe hypoplasia of corpus callosum of probable different genetic basis. From our preliminary observation, it seems that GE cavitations are part of conditions which are also accompanied by severe cerebral structure derangement.

Original languageEnglish
Pages (from-to)1841-1845
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

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