Bilateral consecutive rupture of the quadriceps tendon in a man with BstUI polymorphism of the COL5A1 gene

Umile Giuseppe Longo, Vito Fazio, Maria Luana Poeta, Carla Rabitti, Francesco Franceschi, Nicola Maffulli, Vincenzo Denaro

Research output: Contribution to journalArticlepeer-review

Abstract

A genetic component has been implicated in tendinopathies involving tendon rupture. Type V collagen, a quantitatively minor fibrillar collagen which forms heterotypic fibrils with type I collagen, plays a role in the regulation of the size and configuration of fibrils of the much more abundant component type I collagen. To date, no data on the genetic component of bilateral rupture of the quadriceps tendon have been reported. We describe the presence of BstUI polymorphism of the COL5A1 gene in a man with bilateral rupture of the quadriceps tendon. The COL5A1 (the variant rs12722, BstUI RFLP) can be a candidate gene associated with the development of bilateral quadriceps tendon rupture.

Original languageEnglish
Pages (from-to)514-518
Number of pages5
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Gene
  • Genetics
  • Polymorphism
  • Sports
  • Tendinopathy
  • Tendon

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

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