Bilateral implantation of centromedian-parafascicularis complex and GPi: A new combination of unconventional targets for deep brain stimulation in severe Parkinson disease

Paolo Mazzone, Fabrizio Stocchi, Salvatore Galati, Angelo Insola, Maria Grazia Altibrandi, Nicola Modugno, Domenicantonio Tropepi, Livia Brusa, Alessandro Stefani

Research output: Contribution to journalArticle

Abstract

Objectives. Traditional deep brain stimulation (DBS) at the subthalamic nucleus (STN) has proved to be efficacious on core Parkinsonian symptoms. However, very disabling l-dopa-induced abnormal involuntary movements (AIMs) and axial signs are slightly affected, suggesting that we target less conventional targets. Our candidates for DBS were the globus pallidus internus (GPi) plus the intralaminar thalamic complex (Pf or CM), given its extensive functional links with basal ganglia nuclei. Materials and Methods. The routine utilization of our innovative stereotactic apparatus allows us to implant, at the same time, both the CM-Pf complex together with the GPi in six Parkinson disease patients. Both intraoperative and postoperative neurophysiologic assessments helped us recognize functional subregions while optimizing implantation of electrodes. Unified Parkinson disease rating scale (UPDRS) motor scores, AIMs, and freezing were carefully blindly evaluated for each condition. Results. A significant amelioration of UPDRS scores was achieved by simultaneous activation of both targets. CM-Pf activation was only slightly effective in reducing rigidity and akinesia, but more efficacious on freezing. Not surprisingly, AIMs were peculiarly decreased by the activation of the permanent electro-catheter in the posteroventral GPi. Conclusions. These findings confirm that, in selected patients, it is conceivable to target structures other than the conventional STN in order to maximize clinical benefit.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalNeuromodulation
Volume9
Issue number3
DOIs
Publication statusPublished - Jul 2006

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Globus Pallidus
Deep Brain Stimulation
Dyskinesias
Parkinson Disease
Subthalamic Nucleus
Basal Ganglia
Freezing
Dihydroxyphenylalanine
Electrodes
Catheters

Keywords

  • Deep brain stimulation (DBS)
  • Dyskinesias
  • Extrapyramidal disorders
  • Freezing
  • Intrathalamic complex nuclei
  • Parkinson disease (PD)

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neuroscience(all)

Cite this

Bilateral implantation of centromedian-parafascicularis complex and GPi : A new combination of unconventional targets for deep brain stimulation in severe Parkinson disease. / Mazzone, Paolo; Stocchi, Fabrizio; Galati, Salvatore; Insola, Angelo; Altibrandi, Maria Grazia; Modugno, Nicola; Tropepi, Domenicantonio; Brusa, Livia; Stefani, Alessandro.

In: Neuromodulation, Vol. 9, No. 3, 07.2006, p. 221-228.

Research output: Contribution to journalArticle

Mazzone, Paolo ; Stocchi, Fabrizio ; Galati, Salvatore ; Insola, Angelo ; Altibrandi, Maria Grazia ; Modugno, Nicola ; Tropepi, Domenicantonio ; Brusa, Livia ; Stefani, Alessandro. / Bilateral implantation of centromedian-parafascicularis complex and GPi : A new combination of unconventional targets for deep brain stimulation in severe Parkinson disease. In: Neuromodulation. 2006 ; Vol. 9, No. 3. pp. 221-228.
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