Bilateral lesions of the basal ganglia and thalami (central grey matter)-pictorial review

Sofie Van Cauter, Mariasavina Severino, Rosamaria Ammendola, Brecht Van Berkel, Hrvoje Vavro, Luc van den Hauwe, Zoran Rumboldt

Research output: Contribution to journalReview articlepeer-review


The basal ganglia and thalami are paired deep grey matter structures with extensive metabolic activity that renders them susceptible to injury by various diseases. Most pathological processes lead to bilateral lesions, which may be symmetric or asymmetric, frequently showing characteristic patterns on imaging studies. In this comprehensive pictorial review, the most common and/or typical genetic, acquired metabolic/toxic, infectious, inflammatory, vascular and neoplastic pathologies affecting the central grey matter are subdivided according to the preferential location of the lesions: in the basal ganglia, in the thalami or both. The characteristic imaging findings are described with emphasis on the differential diagnosis and clinical context.

Original languageEnglish
Pages (from-to)1565-1605
Number of pages41
Issue number12
Publication statusPublished - Dec 2020


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