Bilateral motor and premotor cortex hypometabolism in a case of Mills syndrome

Carlo Scialò, Silvia Morbelli, Nicola Girtler, Paola Mandich, Giovanni Luigi Mancardi, Claudia Caponnetto, Flavio Nobili

Research output: Contribution to journalArticlepeer-review


Mills syndrome is a rare condition characterized by slowly progressive upper motor neuron-predominant hemiparesis, belonging to the motor neuron disorder spectrum. Predominantly unilateral primary degeneration of corticospinal pathways is the supposed underlying pathophysiological mechanism. By means of 18F-Fluorodeoxyglucose Positron Emission Tomography, we found significant (Statistical Parametric Mapping, SPM, analysis versus controls, uncorrected p <0.005 at voxel level, p <0.05 at cluster level, corrected for multiple comparisons) hypometabolism in motor and premotor areas of both hemispheres, mainly contralateral to the limbs weakness in a patient with a 10-year history of slowly progressive left-sided hemiparesis. No significant grey matter loss was found on voxel based morphometry (SPM). This supports the hypothesis of a slowly progressive neurodegenerative process involving primary motor and premotor cortex.

Original languageEnglish
Pages (from-to)414-417
Number of pages4
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Issue number5-6
Publication statusPublished - Aug 27 2015


  • ALS
  • Amyotrophic Lateral Sclerosis
  • Mills Syndrome
  • Motor Neuron Disease
  • PLS
  • Primary Lateral Sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'Bilateral motor and premotor cortex hypometabolism in a case of Mills syndrome'. Together they form a unique fingerprint.

Cite this