TY - JOUR
T1 - Bilateral ovarian malakoplakia
T2 - Case report and review of the literature with clinical and diagnostic considerations
AU - Carbone, Riccardo
AU - Bonometti, Arturo
AU - Cassani, Chiara
AU - Lucato, Elena
AU - Rossi, Margherita
AU - Spinillo, Arsenio
AU - Paulli, Marco
AU - Cesari, Stefania
N1 - Publisher Copyright:
© 2020 International Society of Gynecological Pathologists.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1
Y1 - 2021/1
N2 - Malakoplakia is a rare condition in which histiocytic cells accumulate within different organs and tissues, sometimes mimicking neoplasia. Gynecologic involvement is extremely rare and therefore may cause relevant diagnostic confusion for both clinicians and pathologists. In this paper, we described the seventh case of ovarian malakoplakia, and we reviewed the literature to compare it with the previously reported ones. Moreover, we investigated the histologic and molecular differential diagnosis of malakoplakia, with special attention to other histiocytic disorders of gynecologic interest. Finally, we discussed the most relevant points with regard to possible pathogenesis and management. Malakoplakia often represents a forgotten entity that should be remembered preoperatively, when approaching a possible gynecologic neoplasia. Moreover, it is of remarkable importance to differentiate malakoplakia from multisystem histiocytosis involving gynecologic organs. All this would prevent misdiagnosis and overtreatment of such a rare but benign condition.
AB - Malakoplakia is a rare condition in which histiocytic cells accumulate within different organs and tissues, sometimes mimicking neoplasia. Gynecologic involvement is extremely rare and therefore may cause relevant diagnostic confusion for both clinicians and pathologists. In this paper, we described the seventh case of ovarian malakoplakia, and we reviewed the literature to compare it with the previously reported ones. Moreover, we investigated the histologic and molecular differential diagnosis of malakoplakia, with special attention to other histiocytic disorders of gynecologic interest. Finally, we discussed the most relevant points with regard to possible pathogenesis and management. Malakoplakia often represents a forgotten entity that should be remembered preoperatively, when approaching a possible gynecologic neoplasia. Moreover, it is of remarkable importance to differentiate malakoplakia from multisystem histiocytosis involving gynecologic organs. All this would prevent misdiagnosis and overtreatment of such a rare but benign condition.
KW - Gynecopathology
KW - Histiocytosis
KW - Malakoplakia
KW - Michaelis Gutmann
KW - Ovary
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U2 - 10.1097/PGP.0000000000000659
DO - 10.1097/PGP.0000000000000659
M3 - Article
C2 - 31851062
AN - SCOPUS:85097576182
VL - 40
SP - 60
EP - 64
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
SN - 0277-1691
IS - 1
ER -