Bilateral Transcranial Direct Current Stimulation Reshapes Resting-State Brain Networks: A Magnetoencephalography Assessment

Giovanni Pellegrino, Matteo Maran, Cristina Turco, Luca Weis, Giovanni Di Pino, Francesco Piccione, Giorgio Arcara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Transcranial direct current stimulation (tDCS) can noninvasively induce brain plasticity, and it is potentially useful to treat patients affected by neurological conditions. However, little is known about tDCS effects on resting-state brain networks, which are largely involved in brain physiological functions and in diseases. In this randomized, sham-controlled, double-blind study on healthy subjects, we have assessed the effect of bilateral tDCS applied over the sensorimotor cortices on brain and network activity using a whole-head magnetoencephalography system. Bilateral tDCS, with the cathode (-) centered over C4 and the anode (+) centered over C3, reshapes brain networks in a nonfocal fashion. Compared to sham stimulation, tDCS reduces left frontal alpha, beta, and gamma power and increases global connectivity, especially in delta, alpha, beta, and gamma frequencies. The increase of connectivity is consistent across bands and widespread. These results shed new light on the effects of tDCS and may be of help in personalizing treatments in neurological disorders.

Original languageEnglish
Article number2782804
JournalNeural Plasticity
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Magnetoencephalography
Brain
Electrodes
Nervous System Diseases
Double-Blind Method
Transcranial Direct Current Stimulation
Healthy Volunteers
Head

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Bilateral Transcranial Direct Current Stimulation Reshapes Resting-State Brain Networks : A Magnetoencephalography Assessment. / Pellegrino, Giovanni; Maran, Matteo; Turco, Cristina; Weis, Luca; Di Pino, Giovanni; Piccione, Francesco; Arcara, Giorgio.

In: Neural Plasticity, Vol. 2018, 2782804, 01.01.2018.

Research output: Contribution to journalArticle

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