Bile acid malabsorption in cystic fibrosis with and without pancreatic insufficiency

Carla Colombo, Aldo Roda, Enrico Roda, Lucia Piceni Sereni, Antonio Brega, Rita Fugazza, Annamaria Giunta

Research output: Contribution to journalArticlepeer-review

Abstract

Serum conjugated cholic acid (CCA) and conjugated chenodeoxycholic acid (CCDCA) fasting levels were measured in 30 children with cystic fibrosis (CF) without liver involvement, and mean levels were not significantly different from control values. In seven children (four with partially corrected pancreatic insufficiency and three without pancreatic insufficiency) serum levels of both primary bile acids (BAs) were also measured after the ingestion of a standard liquid meal; the values were then compared with those for total and fractional fecal BA excretion. The CCA mean peak increase was significantly reduced in patients with pancreatic insufficiency (p <0.01), as well as in those without pancreatic insufficiency (p <0.05), as compared to controls. The CCDCA mean peak increase was reduced only in patients with pancreatic insufficiency (p <0.01). Fecal results confirmed serum data, showing a significantly increased ex-cretion of cholic and deoxycholic acids in patients without pancreatic insufficiency as compared to controls (p <0.02), despite a similar total BA excretion. In patients with pancreatic insufficiency, total fecal BA levels were markedly increased compared to control values (p <0.001); the fecal percentage of chenodeoxycholic and lithocholic acids was greater than that recorded in patients without pancreatic insufficiency (p <0.05), in agreement with the different behaviour of serum CCDCA postprandial curves for the two groups of patients. The results are consistent with selective malabsorption of cholic acid in CF, independent of the presence of pancreatic insufficiency; they confirm the usefulness of serum BA postprandial determinations in measuring BA malabsorption.

Original languageEnglish
Pages (from-to)556-562
Number of pages7
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume3
Issue number4
Publication statusPublished - 1984

Keywords

  • Bile acids
  • Cystic fibrosis

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Histology
  • Medicine (miscellaneous)
  • Food Science

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