Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease)

Carlo G. Vergani, Angello C. Plancher, Massimo Zuin, Marco Cattaneo, Casimiro Tramaloni, Sergio Maccari, Paola Roma, Alberico L. Catapano

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Abstract

A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B 2. A platelet storage pool deficiency was also found.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalEuropean Journal of Clinical Investigation
Volume14
Issue number1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Medicine(all)

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    Vergani, C. G., Plancher, A. C., Zuin, M., Cattaneo, M., Tramaloni, C., Maccari, S., Roma, P., & Catapano, A. L. (1984). Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease). European Journal of Clinical Investigation, 14(1), 49-54.