Biliary bile acid composition in gastric cancer

M. Fracchia, S. Pellegrino, P. Secreto, M. Calgaro, S. Taraglio, A. Pera, G. Galatola

Research output: Contribution to journalArticle

Abstract

Bile reflux into the stomach has been considered carcinogenic. Secondary bile acids, and in particular deoxycholic acid, have been shown to act experimentally as co-carcinogens in the colon and are increased in patients with colorectal adenocarcinoma. No information is available with respect to biliary bile acid composition in patients with gastric cancer. We studied biliary bile acid composition in 11 patients with gastric cancer and 23 healthy controls. Bile acids were measured using high-performance liquid chromatography. The site of gastric cancer was the antrum in 6 patients and body in 5. There were 6 intestinal-type and 5 diffuse adenocarcinomas. Only 2 patients had Helicobacterpylori infection. Deoxycholic acid constituted 24% ± 2% of biliary bile acid in gastric cancer patients versus 22%±2% in healthy controls (NS). Similarly, no differences were found between the two groups for all other bile acids. Deoxycholic acid constituted 23% ± 3% of biliary bile acid (NS vs. controls) in patients with antral adenocarcinoma and 25%±2% (NS vs. controls) in patients with intestinal-type gastric adenocarcinoma. Gastric adenocarcinoma is not associated with an increase in the more-toxic secondary bile acids, and deoxycholic acid in particular. This reduces the importance of bile acid composition as a promotor in gastric carcinogenesis.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalInternational Journal of Clinical & Laboratory Research
Volume29
Issue number1
DOIs
Publication statusPublished - Apr 1999

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Keywords

  • Bile acids
  • Deoxycholic acid
  • Gastric cancer

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Fracchia, M., Pellegrino, S., Secreto, P., Calgaro, M., Taraglio, S., Pera, A., & Galatola, G. (1999). Biliary bile acid composition in gastric cancer. International Journal of Clinical & Laboratory Research, 29(1), 46-48. https://doi.org/10.1007/s005990050062