Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome

Melania Manco, Marco Castagneto, Giuseppe Nanni, Caterina Guidone, Vincenzo Tondolo, Aldo Virgilio Greco, Giovanni Gasbarrini, Geltrude Mingrone

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. The HAIR-AN syndrome is a rare multisystem disorder in women, that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The IR is likely due to a primary defect of the insulin receptor. Methods: We report the case of a 42-year-old Caucasian woman with HAIR-AN syndrome, impaired glucose tolerance (IGT), mild hyperlipemia, and hypertension, who underwent biliopancreatic diversion (BPD). Results: Within 24 months follow-up after BPD, impaired glucose tolerance, mild hyperlipemia, and hypertension completely reversed. Although insulin sensitivity, estimated by the euglycemic hyperinsulinemic clamp, did not improve, signs and symptoms of hyperandrogenism and acanthosis nigricans resolved fully. Conclusion: In HAIR-AN syndrome, malabsorptive bariatric surgery is effective in improving hyperandrogenism and acanthosis nigricans, with noteworthy esthetic consequences. BPD was followed by disappearance of co-morbidities of the syndrome, such as IGT, hypertension and hyperlipemia.

Original languageEnglish
Pages (from-to)286-289
Number of pages4
JournalObesity Surgery
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Biliopancreatic Diversion
Acanthosis Nigricans
Glucose Intolerance
Hyperlipidemias
Hyperandrogenism
Hypertension
Insulin Resistance
Glucose Clamp Technique
Bariatric Surgery
Insulin Receptor
Esthetics
Signs and Symptoms
Morbidity

Keywords

  • Acanthosis nigricans
  • Bariatric surgery
  • Biliopancreatic diversion
  • HAIR-AN syndrome
  • Hyperandrogenism
  • Insulin resistance
  • Morbid obesity

ASJC Scopus subject areas

  • Surgery

Cite this

Manco, M., Castagneto, M., Nanni, G., Guidone, C., Tondolo, V., Greco, A. V., ... Mingrone, G. (2005). Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome. Obesity Surgery, 15(2), 286-289. https://doi.org/10.1381/0960892053268435

Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome. / Manco, Melania; Castagneto, Marco; Nanni, Giuseppe; Guidone, Caterina; Tondolo, Vincenzo; Greco, Aldo Virgilio; Gasbarrini, Giovanni; Mingrone, Geltrude.

In: Obesity Surgery, Vol. 15, No. 2, 02.2005, p. 286-289.

Research output: Contribution to journalArticle

Manco, M, Castagneto, M, Nanni, G, Guidone, C, Tondolo, V, Greco, AV, Gasbarrini, G & Mingrone, G 2005, 'Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome', Obesity Surgery, vol. 15, no. 2, pp. 286-289. https://doi.org/10.1381/0960892053268435
Manco M, Castagneto M, Nanni G, Guidone C, Tondolo V, Greco AV et al. Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome. Obesity Surgery. 2005 Feb;15(2):286-289. https://doi.org/10.1381/0960892053268435
Manco, Melania ; Castagneto, Marco ; Nanni, Giuseppe ; Guidone, Caterina ; Tondolo, Vincenzo ; Greco, Aldo Virgilio ; Gasbarrini, Giovanni ; Mingrone, Geltrude. / Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome. In: Obesity Surgery. 2005 ; Vol. 15, No. 2. pp. 286-289.
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