Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome

Melania Manco, Marco Castagneto, Giuseppe Nanni, Caterina Guidone, Vincenzo Tondolo, Aldo Virgilio Greco, Giovanni Gasbarrini, Geltrude Mingrone

Research output: Contribution to journalArticlepeer-review


Background. The HAIR-AN syndrome is a rare multisystem disorder in women, that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The IR is likely due to a primary defect of the insulin receptor. Methods: We report the case of a 42-year-old Caucasian woman with HAIR-AN syndrome, impaired glucose tolerance (IGT), mild hyperlipemia, and hypertension, who underwent biliopancreatic diversion (BPD). Results: Within 24 months follow-up after BPD, impaired glucose tolerance, mild hyperlipemia, and hypertension completely reversed. Although insulin sensitivity, estimated by the euglycemic hyperinsulinemic clamp, did not improve, signs and symptoms of hyperandrogenism and acanthosis nigricans resolved fully. Conclusion: In HAIR-AN syndrome, malabsorptive bariatric surgery is effective in improving hyperandrogenism and acanthosis nigricans, with noteworthy esthetic consequences. BPD was followed by disappearance of co-morbidities of the syndrome, such as IGT, hypertension and hyperlipemia.

Original languageEnglish
Pages (from-to)286-289
Number of pages4
JournalObesity Surgery
Issue number2
Publication statusPublished - Feb 2005


  • Acanthosis nigricans
  • Bariatric surgery
  • Biliopancreatic diversion
  • HAIR-AN syndrome
  • Hyperandrogenism
  • Insulin resistance
  • Morbid obesity

ASJC Scopus subject areas

  • Surgery


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