Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis

A. Roitman, A. Lev-Ran, B. I. Carr, D. L. Hwang, G. Barseghian

Research output: Contribution to journalArticle

Abstract

Male F-344 rats (180-200 g) received either a single injection of diethylnitrosamine (DEN) or continuous feeding with 2-acetylaminofluorene (AAF). DEN induced a decrease in the binding of human GH (hGH) to its hepatic Golgi receptors in a dose-dependent manner; the changes were due to a decrease in the number of hGH receptors without significant changes in their affinity. Thirty days after DEN, the binding of hGH returned to normal. After the administration of AAF, the binding of hGH increased owing to the greater number of binding sites, and this effect persisted for the 30-day period of the continuous AAF feeding. In three separate hepatocellular carcinomas, the hGH binding to the Golgi fraction of the tumors was only one quarter of the binding to the peritumorous tissues. We conclude that DEN and AAF, administered acutely for a short time, affect hepatic hGH receptors in a different way, but that hepatocellular carcinomas bind much less hGH than peritumorous or normal tissues. The results show that hepatocarcinogenesis encompasses changes in receptors belonging to different classes.

Original languageEnglish
Pages (from-to)1869-1871
Number of pages3
JournalEndocrinology
Volume118
Issue number5
Publication statusPublished - 1986

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Growth Hormone
2-Acetylaminofluorene
Diethylnitrosamine
Liver
Hepatocellular Carcinoma
Binding Sites
Injections
Neoplasms

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Roitman, A., Lev-Ran, A., Carr, B. I., Hwang, D. L., & Barseghian, G. (1986). Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis. Endocrinology, 118(5), 1869-1871.

Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis. / Roitman, A.; Lev-Ran, A.; Carr, B. I.; Hwang, D. L.; Barseghian, G.

In: Endocrinology, Vol. 118, No. 5, 1986, p. 1869-1871.

Research output: Contribution to journalArticle

Roitman, A, Lev-Ran, A, Carr, BI, Hwang, DL & Barseghian, G 1986, 'Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis', Endocrinology, vol. 118, no. 5, pp. 1869-1871.
Roitman A, Lev-Ran A, Carr BI, Hwang DL, Barseghian G. Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis. Endocrinology. 1986;118(5):1869-1871.
Roitman, A. ; Lev-Ran, A. ; Carr, B. I. ; Hwang, D. L. ; Barseghian, G. / Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis. In: Endocrinology. 1986 ; Vol. 118, No. 5. pp. 1869-1871.
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