Binding of inositol hexakisphosphate to the oxygenated derivative of dromedary (Camelus dromedarius) and human hemoglobin: 31P-NMR study

Paolo Ascenzi; Gino Amiconi; Enrico Rossi; Anna Laura Segre

doi:10.1016/0162-0134(89)84015-2

Binding of inositol hexakisphosphate to the oxygenated derivative of dromedary (Camelus dromedarius) and human hemoglobin: 31P-NMR study

Paolo Ascenzi, Gino Amiconi, Enrico Rossi, Anna Laura Segre

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Binding of inositol hexakisphosphate (IHP) to the oxygenated derivative of dromedary (Camelus dromedarius) and human hemoglobin (Hb) was investigated by ¹³P-NMR. The results obtained show that dromedary Hb binds, with different affinity, two IHP molecules per tetramer at distinct sites, while human Hb binds only one IHP molecule per tetramer.

Original language	English
Pages (from-to)	247-253
Number of pages	7
Journal	Journal of Inorganic Biochemistry
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/0162-0134(89)84015-2
Publication status	Published - 1989

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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abstract = "Binding of inositol hexakisphosphate (IHP) to the oxygenated derivative of dromedary (Camelus dromedarius) and human hemoglobin (Hb) was investigated by 13P-NMR. The results obtained show that dromedary Hb binds, with different affinity, two IHP molecules per tetramer at distinct sites, while human Hb binds only one IHP molecule per tetramer.",

author = "Paolo Ascenzi and Gino Amiconi and Enrico Rossi and Segre, {Anna Laura}",

year = "1989",

doi = "10.1016/0162-0134(89)84015-2",

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AU - Amiconi, Gino

AU - Rossi, Enrico

AU - Segre, Anna Laura

PY - 1989

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N2 - Binding of inositol hexakisphosphate (IHP) to the oxygenated derivative of dromedary (Camelus dromedarius) and human hemoglobin (Hb) was investigated by 13P-NMR. The results obtained show that dromedary Hb binds, with different affinity, two IHP molecules per tetramer at distinct sites, while human Hb binds only one IHP molecule per tetramer.

AB - Binding of inositol hexakisphosphate (IHP) to the oxygenated derivative of dromedary (Camelus dromedarius) and human hemoglobin (Hb) was investigated by 13P-NMR. The results obtained show that dromedary Hb binds, with different affinity, two IHP molecules per tetramer at distinct sites, while human Hb binds only one IHP molecule per tetramer.

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