Binding of Streptococcus gordonii to extracellular matrix proteins

Barbara Giomarelli, Livia Visai, Karolin Hijazi, Simonetta Rindi, Michela Ponzio, Francesco Iannelli, Pietro Speziale, Gianni Pozzi

Research output: Contribution to journalArticlepeer-review


Knock-out mutants of Streptococcus gordonii Challis were constructed and assayed for binding to extracellular matrix proteins (EMPs) by enzyme-linked immunosorbent assay (ELISA). It was shown that (i) the mutant lacking the cell wall polysaccharide receptor could no longer bind type I and type II collagen, (ii) the mutant lacking the fibronectin-binding proteins CshA and FbpA was also strongly impaired in collagen binding and (iii) the mutant lacking the methionine sulfoxide reductase MsrA was significantly impaired in fibronectin binding. Our results indicate that binding to EMPs by S. gordonii is a multifactorial process controlled by genes located at three different chromosomal sites.

Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalFEMS Microbiology Letters
Issue number2
Publication statusPublished - Dec 2006


  • Extracellular matrix proteins (EMPs)
  • Microbial adhesins
  • Microbial surface components recognizing adhesive matrix molecules (MSCRAMMs)
  • Oral streptococci
  • Streptococcus gordonii

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology


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