Binge eating and fast cognitive worsening in an early-onset bvFTD patient carrying C9ORF72 expansion

G. Talarico, M. Canevelli, G. Tosto, P. Piscopo, A. Confaloni, D. Galimberti, C. Fenoglio, E. Scarpini, M. Gasparini, G. Bruno

Research output: Contribution to journalArticle

Abstract

An expanded hexanucleotide (GGGGCC) repeat in a non-coding promoter region of open reading frame 72 of chromosome 9 (C9ORF72) has been recently identified as a major cause of familial and sporadic frontotemporal lobar degeneration. We describe the clinical picture of a 64-year-old woman carrying the hexanucleotide repeat expansion, who developed a sporadic early-onset form of behavioral variant frontotemporal dementia characterized by the occurrence of uncommon behavioral manifestations such as binge eating disturbance and by a rapid worsening of cognitive abilities. Our report confirms previous studies asserting that C9ORF72 repeats may sustain heterogeneous clinical syndromes.

Original languageEnglish
Pages (from-to)543-547
Number of pages5
JournalNeurocase
Volume21
Issue number5
DOIs
Publication statusPublished - Sep 3 2015

Keywords

  • behavioral disturbances in dementia
  • behavioral variant frontotemporal dementia
  • binge eating disorder in frontotemporal dementia
  • C9ORF72 repeats
  • frontotemporal dementia associated with C9ORF72

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

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