Binswanger's disease: A review of the literature and a personal contribution

T. Sacquegna, S. Guttmann, S. Giuliani, R. Agati, R. Daidone, A. Morreale, G. Ambrosetto, R. Gallassi

Research output: Contribution to journalArticle

Abstract

Binswanger's disease is the name which has been given to a form of subcortical vascular dementia. These patients have a particular clinical profile which progressively includes strokes, gait disorder, pseudobulbar signs and cognitive impairment suggesting dysfunction of the prefrontal cortex. The radiological pattern of hypodensity of the white matter on CT scan (or an increased MRI signal), albeit much debated, seems to be more closely associated with hypertension, previous strokes and neuropsychological defects. Binswanger's disease probably represents the end stage of a pathological process in which hypertensive arteriolopathy, demyelination of the centra semiovale and deep infarcts all play a role.

Original languageEnglish
Pages (from-to)20-22
Number of pages3
JournalEuropean Neurology
Volume29
Issue numberSUPPL. 2
Publication statusPublished - 1989

Keywords

  • Binswanger's disease
  • dementia
  • leuko-araiosis
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Binswanger's disease: A review of the literature and a personal contribution'. Together they form a unique fingerprint.

  • Cite this

    Sacquegna, T., Guttmann, S., Giuliani, S., Agati, R., Daidone, R., Morreale, A., Ambrosetto, G., & Gallassi, R. (1989). Binswanger's disease: A review of the literature and a personal contribution. European Neurology, 29(SUPPL. 2), 20-22.