Binswanger's disease: A review of the literature and a personal contribution

T. Sacquegna, S. Guttmann, S. Giuliani, R. Agati, R. Daidone, A. Morreale, G. Ambrosetto, R. Gallassi

Research output: Contribution to journalArticlepeer-review


Binswanger's disease is the name which has been given to a form of subcortical vascular dementia. These patients have a particular clinical profile which progressively includes strokes, gait disorder, pseudobulbar signs and cognitive impairment suggesting dysfunction of the prefrontal cortex. The radiological pattern of hypodensity of the white matter on CT scan (or an increased MRI signal), albeit much debated, seems to be more closely associated with hypertension, previous strokes and neuropsychological defects. Binswanger's disease probably represents the end stage of a pathological process in which hypertensive arteriolopathy, demyelination of the centra semiovale and deep infarcts all play a role.

Original languageEnglish
Pages (from-to)20-22
Number of pages3
JournalEuropean Neurology
Issue numberSUPPL. 2
Publication statusPublished - 1989


  • Binswanger's disease
  • dementia
  • leuko-araiosis
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology


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