Bio-incompatibility and Th2 polarization during regular dialysis treatment

Carmelo Libetta, Vincenzo Sepe, Antonio Dal Canton

Research output: Contribution to journalArticle


Long-term hemodialysis treatment results in chronic monocyte activation with cytokine release. It generates Treg induction with potential immune dysfunction and associated clinical complications. Recent immunological data and preliminary clinical evidence suggest that synthetic polymers and vitamin E coated membranes are associated with a significant improvement in hemodialysis tolerance when compared to cellulose membranes. The aim of this review is to update cytokine release, T-cell polarization, and its clinical impact in patients under extracorporeal hemodialysis comparing traditional cellulose to synthetic/vitamin E coated membranes.

Original languageEnglish
Pages (from-to)608-625
Number of pages18
JournalInternational Reviews of Immunology
Issue number6
Publication statusPublished - Nov 1 2010



  • acute phase response
  • bio-incompatibility
  • biocompatibility
  • cytokines
  • dialyzer
  • hemodialysis
  • hemodialysis membranes
  • inflammation
  • liver
  • lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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