Bio-incompatibility and Th2 polarization during regular dialysis treatment

Carmelo Libetta, Vincenzo Sepe, Antonio Dal Canton

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Long-term hemodialysis treatment results in chronic monocyte activation with cytokine release. It generates Treg induction with potential immune dysfunction and associated clinical complications. Recent immunological data and preliminary clinical evidence suggest that synthetic polymers and vitamin E coated membranes are associated with a significant improvement in hemodialysis tolerance when compared to cellulose membranes. The aim of this review is to update cytokine release, T-cell polarization, and its clinical impact in patients under extracorporeal hemodialysis comparing traditional cellulose to synthetic/vitamin E coated membranes.

Original languageEnglish
Pages (from-to)608-625
Number of pages18
JournalInternational Reviews of Immunology
Volume29
Issue number6
DOIs
Publication statusPublished - Nov 1 2010

Fingerprint

Renal Dialysis
Dialysis
Vitamin E
Cellulose
Membranes
Cytokines
Monocytes
Polymers
Therapeutics
T-Lymphocytes

Keywords

  • acute phase response
  • bio-incompatibility
  • biocompatibility
  • cytokines
  • dialyzer
  • hemodialysis
  • hemodialysis membranes
  • inflammation
  • liver
  • lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Bio-incompatibility and Th2 polarization during regular dialysis treatment. / Libetta, Carmelo; Sepe, Vincenzo; Canton, Antonio Dal.

In: International Reviews of Immunology, Vol. 29, No. 6, 01.11.2010, p. 608-625.

Research output: Contribution to journalArticle

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