Bio-Pathological Factors of Prognostic Value in Colorectal Adenocarcinomas

M. Mottolese, S. Buglioli, G. Piperno, I. Sperduti, D. Giannarelli, C. D'Angelo, M. Cosimelli

Research output: Contribution to journalArticlepeer-review

Abstract

About 40% of patients bearing a colorectal carcinoma will develop local or distant tumor recurrences. Integrated analyses of biopathological markers, predictive of tumor aggressiveness, may offer a more rational approach to adjuvant therapy planning. To this end we analyzed the correlation between p53 accumulation, bcl-2 expression with cell proliferation, DNA ploidy, and conventional histological parameters, by testing the prognostic significance of these variables in a series of 214 patients bearing a colorectal carcinoma. When these parameters were examined in the univariate analysis, significantly shorter disease free and overall survival were observed in patients bearing p53+ and bcl-2-tumors. In the multivariate analysis p53 accumulation and bcl-2 expression emerged as independent predictors respectively of worse and better clinical outcome also in Dukes' B stage identifying patients at higher risk to develop liver metastases. These results indicate that in colorectal adenocarcinomas a biological profile, based on the combined evaluation of p53 and bcl-2, can be useful in identifying high risk patients to be enrolled in an adjuvant setting mainly in early stage of the disease.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalJournal of Experimental and Clinical Cancer Research
Volume22
Issue number4 SUPPL.
Publication statusPublished - Dec 2003

Keywords

  • Bio-marker
  • Colon cancer
  • Liver metastasis
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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