Abstract
Chronic wounds are the result of alterations in the complex series of events of physiological wound healing. In particular, the prolonged inflammation results in increased protease activity, in the degradation of extracellular matrix (ECM) and of growth factors (GFs). The relevance of platelet GFs in maintaining and restoring the complex equilibrium of different moments in wound healing is well recognized. Moreover, the observed decrease of their levels in chronic wounds suggested a possible therapeutic role of the external application to the wounds. It has been also pointed out that tissue regeneration can be more efficiently obtained by the synergic use of different GFs. Platelet derivatives such as platelet-rich plasma (PRP) and platelet lysate (PL) are able to release GFs in a balanced pool. Their therapeutic use in regenerative medicine and wound healing has been therefore more and more frequently proposed in clinical trials and in the literature. The development of a suitable formulation able to control the GFs release rate, to protect the GFs, and to assure their prolonged contact with the wound site, is of paramount importance for the therapeutic success. The present review considers some formulation approaches for PRP and PL application to wounds.
| Original language | English |
|---|---|
| Pages (from-to) | 472-483 |
| Number of pages | 12 |
| Journal | Current Drug Delivery |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Drug delivery systems
- Extracellular matrix (ECM)
- Platelet lysate
- Platelet-rich plasma
- Skin regeneration
- Wound healing
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Bioactive medications for the delivery of platelet derivatives to skin wounds. / Bonferoni, Maria Cristina; Rossi, Silvia; Sandri, Giuseppina; Caramella, Carla; Fante, Claudia Del; Perotti, Cesare; Miele, Dalila; Vigani, Barbara; Ferrari, Franca.
In: Current Drug Delivery, Vol. 16, No. 5, 01.01.2019, p. 472-483.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Bioactive medications for the delivery of platelet derivatives to skin wounds
AU - Bonferoni, Maria Cristina
AU - Rossi, Silvia
AU - Sandri, Giuseppina
AU - Caramella, Carla
AU - Fante, Claudia Del
AU - Perotti, Cesare
AU - Miele, Dalila
AU - Vigani, Barbara
AU - Ferrari, Franca
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Chronic wounds are the result of alterations in the complex series of events of physiological wound healing. In particular, the prolonged inflammation results in increased protease activity, in the degradation of extracellular matrix (ECM) and of growth factors (GFs). The relevance of platelet GFs in maintaining and restoring the complex equilibrium of different moments in wound healing is well recognized. Moreover, the observed decrease of their levels in chronic wounds suggested a possible therapeutic role of the external application to the wounds. It has been also pointed out that tissue regeneration can be more efficiently obtained by the synergic use of different GFs. Platelet derivatives such as platelet-rich plasma (PRP) and platelet lysate (PL) are able to release GFs in a balanced pool. Their therapeutic use in regenerative medicine and wound healing has been therefore more and more frequently proposed in clinical trials and in the literature. The development of a suitable formulation able to control the GFs release rate, to protect the GFs, and to assure their prolonged contact with the wound site, is of paramount importance for the therapeutic success. The present review considers some formulation approaches for PRP and PL application to wounds.
AB - Chronic wounds are the result of alterations in the complex series of events of physiological wound healing. In particular, the prolonged inflammation results in increased protease activity, in the degradation of extracellular matrix (ECM) and of growth factors (GFs). The relevance of platelet GFs in maintaining and restoring the complex equilibrium of different moments in wound healing is well recognized. Moreover, the observed decrease of their levels in chronic wounds suggested a possible therapeutic role of the external application to the wounds. It has been also pointed out that tissue regeneration can be more efficiently obtained by the synergic use of different GFs. Platelet derivatives such as platelet-rich plasma (PRP) and platelet lysate (PL) are able to release GFs in a balanced pool. Their therapeutic use in regenerative medicine and wound healing has been therefore more and more frequently proposed in clinical trials and in the literature. The development of a suitable formulation able to control the GFs release rate, to protect the GFs, and to assure their prolonged contact with the wound site, is of paramount importance for the therapeutic success. The present review considers some formulation approaches for PRP and PL application to wounds.
KW - Drug delivery systems
KW - Extracellular matrix (ECM)
KW - Platelet lysate
KW - Platelet-rich plasma
KW - Skin regeneration
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85065886776&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065886776&partnerID=8YFLogxK
U2 - 10.2174/1381612825666190320154406
DO - 10.2174/1381612825666190320154406
M3 - Review article
C2 - 30894109
AN - SCOPUS:85065886776
VL - 16
SP - 472
EP - 483
JO - Current Drug Delivery
JF - Current Drug Delivery
SN - 1567-2018
IS - 5
ER -