Bioactivity modulation of bioactive materials in view of their application in osteoporotic patients

M. Mattioli Belmonte, A. De Benedittis, R. A A Muzzarelli, P. Mengucci, G. Biagini, M. G. Gandolfi, C. Zucchini, A. Krajewski, A. Ravaglioli, E. Roncari, M. Fini, R. Giardino

Research output: Contribution to journalArticlepeer-review


The application of bioactive ceramic coatings to prostheses confers strength to a material (ceramic or biological glass) that exerts beneficial effects on bone-tissue growth but that itself lacks the toughness and stability required of an implant device. The rate of bioactivity is related to the chemical reactivity of the material and causes interface dissolution, precipitation and ion-exchange reactions. Ceramics may differ in sintering temperature and thus exhibit differences in their in vitro dissolution features and in vivo performance. To test these effects, in vitro and in vivo studies were carried out on two biocompatible biological glasses and a ceramic of proven bioactivity in view of their potential utilization as covering materials. In addition, a modified chitosan was adsorbed on the surface of a series of hydroxyapatite (HA) samples. Human fibroblasts and/or osteoblasts were used for the in vitro tests, and normal (INT) and osteoporotic (OVX) rats, normal rabbits and sheep for the in vivo studies. Similar chemical changes were observed in both glasses, suggesting that these materials underwent modifications directly dependent on their biological environment. The in vivo tests point to the possibility of improving the bioactivity of ceramic substrates with chitosan. However, the different behaviour of the materials in vitro and in vivo suggests that these tests should be conducted in parallel.

Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalJournal of Materials Science: Materials in Medicine
Issue number9
Publication statusPublished - Sep 1998

ASJC Scopus subject areas

  • Biophysics
  • Chemical Engineering(all)
  • Bioengineering


Dive into the research topics of 'Bioactivity modulation of bioactive materials in view of their application in osteoporotic patients'. Together they form a unique fingerprint.

Cite this