Bioavailability and platelet aggregation inhibitory activity of solufenum. A comparison with ibuprofen

R. Latini, S. Villa, M. Gerna, G. Tognoni, G. de Gaetano

Research output: Contribution to journalArticlepeer-review

Abstract

Bioavailability and platelet aggregation inhibitory activity of the lysine salt of ibuprofen (solufenum) were compared with those of the parent molecule in 5 healthy male volunteers. The study had a randomized, cross-over design. The average peak plasma level and the area under the curve were higher when solufenum was administered orally as compared to the same preparation given i.m. or as compared to oral ibuprofen. However, the bioavailability of the 3 preparations studied was not significantly different. In contrast, the inhibitory effect on adrenaline-induced platelet aggregation appeared significantly earlier after the administration of solufenum than after ibuprofen. The clinical relevance of these findings is discussed.

Original languageEnglish
Pages (from-to)492-495
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume15
Issue number10
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Bioavailability and platelet aggregation inhibitory activity of solufenum. A comparison with ibuprofen'. Together they form a unique fingerprint.

Cite this