Bioavailability and related heart function index of digoxin capsules and tablets in cardiac patients

E. Astorri, G. Bianchi, G. la Canna, D. Assanelli, O. Visioli, A. Marzo

Research output: Contribution to journalArticle

Abstract

A loading dose of digoxin (750 μg) in two commercial formulations was administered to 14 patients with heart disease according to a crossover design. One formulation consisted of soft gelatin capsules containing a solution of digoxin; the other formulation was compressed tablets. All parameters investigated, i.e., serum peak height, time of the peak, area under the serum level-time curve (AUC), and area above the Q-S 2I (electromechanical systole) decrease (obtained from polycardiographic evaluation), showed better bioavailability of digoxin capsules than tablets, averaging 36.3%. The better bioavailability of digoxin capsules than tablets seems to be more evident in heart disease patients than that encountered previously in healthy subjects. The AUC and the area above the Q-S 2I decrease were linearly correlated only with digoxin capsules.

Original languageEnglish
Pages (from-to)104-106
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume68
Issue number1
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

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    Astorri, E., Bianchi, G., la Canna, G., Assanelli, D., Visioli, O., & Marzo, A. (1979). Bioavailability and related heart function index of digoxin capsules and tablets in cardiac patients. Journal of Pharmaceutical Sciences, 68(1), 104-106.