BIODISPONIBILITA DI UN PREPARATO RITARDO DI AMINOFILLINA

Translated title of the contribution: Bioavailability of a slow absorption aminophylline product

M. B. Regazzi, E. Guarnone, A. Bartoli

Research output: Contribution to journalArticle

Abstract

Absorption of theophylline from one commercial product labelled as aminophylline systained release was compared to the absorption from an oral solution of aminophylline in a single-dose bioavailability study. Aminomal-R tablets had a bioavailability (101.2 ± 19) statistically indistinguishable from that of the standard but showed significantly slower absorption (peak times of 3.6 ± 1.1 h vs 1.3 ± 0.8 h) and lower peak plasma concentrations (16.8 ± 4.7 mg/l/l g aminoph. dose vs 21.1 ± 4.2 mg/l/l g aminoph. dose). Projections of plasma concentrations upon multiple dosing were made from single dose data: the dosage interval (every 12 h) concentration ratio which reflects both the frequency of dosing and the entry of the drug into and removal from the body was 1.8 vs 3.1.

Translated title of the contributionBioavailability of a slow absorption aminophylline product
Original languageItalian
Pages (from-to)641-645
Number of pages5
JournalMinerva Medica
Volume76
Issue number13
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Medicine(all)

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