Abstract
Absorption of theophylline from one commercial product labelled as aminophylline systained release was compared to the absorption from an oral solution of aminophylline in a single-dose bioavailability study. Aminomal-R tablets had a bioavailability (101.2 ± 19) statistically indistinguishable from that of the standard but showed significantly slower absorption (peak times of 3.6 ± 1.1 h vs 1.3 ± 0.8 h) and lower peak plasma concentrations (16.8 ± 4.7 mg/l/l g aminoph. dose vs 21.1 ± 4.2 mg/l/l g aminoph. dose). Projections of plasma concentrations upon multiple dosing were made from single dose data: the dosage interval (every 12 h) concentration ratio which reflects both the frequency of dosing and the entry of the drug into and removal from the body was 1.8 vs 3.1.
| Original language | Italian |
|---|---|
| Pages (from-to) | 641-645 |
| Number of pages | 5 |
| Journal | Minerva Medica |
| Volume | 76 |
| Issue number | 13 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Medicine(all)
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BIODISPONIBILITA DI UN PREPARATO RITARDO DI AMINOFILLINA. / Regazzi, M. B.; Guarnone, E.; Bartoli, A.
In: Minerva Medica, Vol. 76, No. 13, 1985, p. 641-645.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - BIODISPONIBILITA DI UN PREPARATO RITARDO DI AMINOFILLINA
AU - Regazzi, M. B.
AU - Guarnone, E.
AU - Bartoli, A.
PY - 1985
Y1 - 1985
N2 - Absorption of theophylline from one commercial product labelled as aminophylline systained release was compared to the absorption from an oral solution of aminophylline in a single-dose bioavailability study. Aminomal-R tablets had a bioavailability (101.2 ± 19) statistically indistinguishable from that of the standard but showed significantly slower absorption (peak times of 3.6 ± 1.1 h vs 1.3 ± 0.8 h) and lower peak plasma concentrations (16.8 ± 4.7 mg/l/l g aminoph. dose vs 21.1 ± 4.2 mg/l/l g aminoph. dose). Projections of plasma concentrations upon multiple dosing were made from single dose data: the dosage interval (every 12 h) concentration ratio which reflects both the frequency of dosing and the entry of the drug into and removal from the body was 1.8 vs 3.1.
AB - Absorption of theophylline from one commercial product labelled as aminophylline systained release was compared to the absorption from an oral solution of aminophylline in a single-dose bioavailability study. Aminomal-R tablets had a bioavailability (101.2 ± 19) statistically indistinguishable from that of the standard but showed significantly slower absorption (peak times of 3.6 ± 1.1 h vs 1.3 ± 0.8 h) and lower peak plasma concentrations (16.8 ± 4.7 mg/l/l g aminoph. dose vs 21.1 ± 4.2 mg/l/l g aminoph. dose). Projections of plasma concentrations upon multiple dosing were made from single dose data: the dosage interval (every 12 h) concentration ratio which reflects both the frequency of dosing and the entry of the drug into and removal from the body was 1.8 vs 3.1.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022435234&partnerID=8YFLogxK
M3 - Articolo
VL - 76
SP - 641
EP - 645
JO - Minerva Medicolegale e Archivio di Antropologia Criminale
JF - Minerva Medicolegale e Archivio di Antropologia Criminale
SN - 0026-4806
IS - 13
ER -