Abstract
The bioavailability of α-tocopherol acetate and α-tocopherol (vitamin E) was assessed in male rabbits given 50 mg kg-1 doses according to a randomized design. After intramuscular injection of α-tocopherol acetate in colloidal aqueous solution, a mean absolute bioavailability of 65% was calculated for the acetate and 35% for the physiologically active compound, α-tocopherol. Comparison of the kinetic profiles after intravenous and intramuscular administration of the acetate and intravenous injection of α-tocopherol, revealed absorption of α-tocopherol acetate from the site of injection and hydrolysis of the acetate to be potential limiting steps in the bioavailability of α-tocopherol. Intramuscularly injected α-tocopherol acetate in olive oil (the only formulation available in a few European countries) proved completely bio-unavailable. It thus appears necessary to re-assess the utility of current vitamin E supplementation, since the only formulations available offer poor bioavailability.
| Original language | English |
|---|---|
| Pages (from-to) | 415-417 |
| Number of pages | 3 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 41 |
| Issue number | 6 |
| Publication status | Published - 1989 |
Fingerprint
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
Cite this
Bioavailability of intramuscular vitamin E acetate in rabbits. / Pedraz, J. L.; Calvo, B.; Bortolotti, A.; Celardo, A.; Bonati, M.
In: Journal of Pharmacy and Pharmacology, Vol. 41, No. 6, 1989, p. 415-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bioavailability of intramuscular vitamin E acetate in rabbits
AU - Pedraz, J. L.
AU - Calvo, B.
AU - Bortolotti, A.
AU - Celardo, A.
AU - Bonati, M.
PY - 1989
Y1 - 1989
N2 - The bioavailability of α-tocopherol acetate and α-tocopherol (vitamin E) was assessed in male rabbits given 50 mg kg-1 doses according to a randomized design. After intramuscular injection of α-tocopherol acetate in colloidal aqueous solution, a mean absolute bioavailability of 65% was calculated for the acetate and 35% for the physiologically active compound, α-tocopherol. Comparison of the kinetic profiles after intravenous and intramuscular administration of the acetate and intravenous injection of α-tocopherol, revealed absorption of α-tocopherol acetate from the site of injection and hydrolysis of the acetate to be potential limiting steps in the bioavailability of α-tocopherol. Intramuscularly injected α-tocopherol acetate in olive oil (the only formulation available in a few European countries) proved completely bio-unavailable. It thus appears necessary to re-assess the utility of current vitamin E supplementation, since the only formulations available offer poor bioavailability.
AB - The bioavailability of α-tocopherol acetate and α-tocopherol (vitamin E) was assessed in male rabbits given 50 mg kg-1 doses according to a randomized design. After intramuscular injection of α-tocopherol acetate in colloidal aqueous solution, a mean absolute bioavailability of 65% was calculated for the acetate and 35% for the physiologically active compound, α-tocopherol. Comparison of the kinetic profiles after intravenous and intramuscular administration of the acetate and intravenous injection of α-tocopherol, revealed absorption of α-tocopherol acetate from the site of injection and hydrolysis of the acetate to be potential limiting steps in the bioavailability of α-tocopherol. Intramuscularly injected α-tocopherol acetate in olive oil (the only formulation available in a few European countries) proved completely bio-unavailable. It thus appears necessary to re-assess the utility of current vitamin E supplementation, since the only formulations available offer poor bioavailability.
UR - http://www.scopus.com/inward/record.url?scp=0024318249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024318249&partnerID=8YFLogxK
M3 - Article
VL - 41
SP - 415
EP - 417
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 6
ER -