Bioavailability of intramuscular vitamin E acetate in rabbits

J. L. Pedraz, B. Calvo, A. Bortolotti, A. Celardo, M. Bonati

Research output: Contribution to journalArticlepeer-review


The bioavailability of α-tocopherol acetate and α-tocopherol (vitamin E) was assessed in male rabbits given 50 mg kg-1 doses according to a randomized design. After intramuscular injection of α-tocopherol acetate in colloidal aqueous solution, a mean absolute bioavailability of 65% was calculated for the acetate and 35% for the physiologically active compound, α-tocopherol. Comparison of the kinetic profiles after intravenous and intramuscular administration of the acetate and intravenous injection of α-tocopherol, revealed absorption of α-tocopherol acetate from the site of injection and hydrolysis of the acetate to be potential limiting steps in the bioavailability of α-tocopherol. Intramuscularly injected α-tocopherol acetate in olive oil (the only formulation available in a few European countries) proved completely bio-unavailable. It thus appears necessary to re-assess the utility of current vitamin E supplementation, since the only formulations available offer poor bioavailability.

Original languageEnglish
Pages (from-to)415-417
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Issue number6
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology


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