Bioavailability of intramuscular vitamin E acetate in rabbits

J. L. Pedraz, B. Calvo, A. Bortolotti, A. Celardo, M. Bonati

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The bioavailability of α-tocopherol acetate and α-tocopherol (vitamin E) was assessed in male rabbits given 50 mg kg-1 doses according to a randomized design. After intramuscular injection of α-tocopherol acetate in colloidal aqueous solution, a mean absolute bioavailability of 65% was calculated for the acetate and 35% for the physiologically active compound, α-tocopherol. Comparison of the kinetic profiles after intravenous and intramuscular administration of the acetate and intravenous injection of α-tocopherol, revealed absorption of α-tocopherol acetate from the site of injection and hydrolysis of the acetate to be potential limiting steps in the bioavailability of α-tocopherol. Intramuscularly injected α-tocopherol acetate in olive oil (the only formulation available in a few European countries) proved completely bio-unavailable. It thus appears necessary to re-assess the utility of current vitamin E supplementation, since the only formulations available offer poor bioavailability.

Original languageEnglish
Pages (from-to)415-417
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume41
Issue number6
Publication statusPublished - 1989

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Tocopherols
alpha-Tocopherol
Vitamin E
Biological Availability
Acetates
Rabbits
Intramuscular Injections
Intravenous Injections
Intravenous Administration
Hydrolysis
Injections

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Pedraz, J. L., Calvo, B., Bortolotti, A., Celardo, A., & Bonati, M. (1989). Bioavailability of intramuscular vitamin E acetate in rabbits. Journal of Pharmacy and Pharmacology, 41(6), 415-417.

Bioavailability of intramuscular vitamin E acetate in rabbits. / Pedraz, J. L.; Calvo, B.; Bortolotti, A.; Celardo, A.; Bonati, M.

In: Journal of Pharmacy and Pharmacology, Vol. 41, No. 6, 1989, p. 415-417.

Research output: Contribution to journalArticle

Pedraz, JL, Calvo, B, Bortolotti, A, Celardo, A & Bonati, M 1989, 'Bioavailability of intramuscular vitamin E acetate in rabbits', Journal of Pharmacy and Pharmacology, vol. 41, no. 6, pp. 415-417.
Pedraz, J. L. ; Calvo, B. ; Bortolotti, A. ; Celardo, A. ; Bonati, M. / Bioavailability of intramuscular vitamin E acetate in rabbits. In: Journal of Pharmacy and Pharmacology. 1989 ; Vol. 41, No. 6. pp. 415-417.
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