BIODISPONIBILITA DEL NICORANDIL DOPO SOMMINISTRAZIONE ORALE IN DOSE SINGOLA DI PREPARATI DA 10 E DA 20 MG

Translated title of the contribution: Bioavailability of nicorandil after a single oral dose administration of 10 or 20 mg

M. Molinaro, P. Villani, I. Buggia, I. Iacona, C. Zoia, M. B. Regazzi, R. Rondanelli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To evaluate the bioavailability of 4 different formulations of nicorandil, 10 mg and 20 mg (Bracco) versus 10 mg and 20 mg (Merck), we have carried out a study involving 24 young healthy volunteers. The drug was administered in single oral dose and the plasma concentration levels were evaluated by HPLC method. From the results obtained, we have seen that both the 2 products of 10 mg (A and B) and the 2 products of 20 mg (C and D) are equivalent and have high relative bioavailability: it reaches the values of 96.5% (A versus B) and 120% (C versus D). As regards the 2 formulation of 20 mg, the results of bioavailability are confirmed by data obtained from dissolution study in vitro, where the dissolution is almost complete in 30 minutes.

Original languageItalian
Pages (from-to)375-379
Number of pages5
JournalBollettino Chimico Farmaceutico
Volume131
Issue number10
Publication statusPublished - 1992

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Nicorandil
Biological Availability
Oral Administration
Healthy Volunteers
High Pressure Liquid Chromatography
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Molecular Medicine

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BIODISPONIBILITA DEL NICORANDIL DOPO SOMMINISTRAZIONE ORALE IN DOSE SINGOLA DI PREPARATI DA 10 E DA 20 MG. / Molinaro, M.; Villani, P.; Buggia, I.; Iacona, I.; Zoia, C.; Regazzi, M. B.; Rondanelli, R.

In: Bollettino Chimico Farmaceutico, Vol. 131, No. 10, 1992, p. 375-379.

Research output: Contribution to journalArticle

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abstract = "To evaluate the bioavailability of 4 different formulations of nicorandil, 10 mg and 20 mg (Bracco) versus 10 mg and 20 mg (Merck), we have carried out a study involving 24 young healthy volunteers. The drug was administered in single oral dose and the plasma concentration levels were evaluated by HPLC method. From the results obtained, we have seen that both the 2 products of 10 mg (A and B) and the 2 products of 20 mg (C and D) are equivalent and have high relative bioavailability: it reaches the values of 96.5{\%} (A versus B) and 120{\%} (C versus D). As regards the 2 formulation of 20 mg, the results of bioavailability are confirmed by data obtained from dissolution study in vitro, where the dissolution is almost complete in 30 minutes.",
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AU - Molinaro, M.

AU - Villani, P.

AU - Buggia, I.

AU - Iacona, I.

AU - Zoia, C.

AU - Regazzi, M. B.

AU - Rondanelli, R.

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