Bioavailability of oral isbufylline in rabbits

A. Celardo, G. Dell'elba, M. Bonati

Research output: Contribution to journalArticle

Abstract

The bioavailability of isbufylline was assessed in male rabbits given 12 mg/kg i.v. (intravenous) or per os (oral) according to a randomized design. The concentrations of unbound (fu - 54.0) isbufylline were considered in plasma as a function of time, after i.v. and oral administration. After oral adniinistration in saline solution, a mean absolute oral bioavailability of 59.6% was calculated. The drug is rapidly absorbed and the comparison of the kinetic profiles after i.v. and per os administration, revealed a rapid elimination : t1/2 27.3 and 28.8 min respectively, and a total body clearance of 67.06 ml/min/kg. Urinary recovery 0-48 h accounted for less than 1 % of the dose.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 1992

Keywords

  • bioavailability
  • Isbufylline
  • rabbit
  • urinary excretion

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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