Biochemical and behavioural changes induced by isolation in rats

L. Valzelli, S. Garattini

Research output: Contribution to journalArticlepeer-review


Rats isolated for a period of 6 weeks developed 3 different patterns of behaviour towards mice: "friendly", "muricide" and "indifferent". The levels of brain amines (5-hydroxytryptamine, noradrenaline and dopamine) and 5-hydroxyindoleacetic acid did not differ from those in the control animals, but the turnover of brain amines was modified. The turnover rate of brain 5-hydroxytryptamine increased in "friendly" rats and decreased in "muricide" and "indifferent" animals. Brainstem noradrenaline turnover time decreased in "friendly" and in "muricide" animals but did not change in "indifferent" rats. The turnover rate of striatal dopamine decreased in "friendly" rats but remained unchanged in "muricide" and "indifferent" animals.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
Issue number1
Publication statusPublished - 1972

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology


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