Indagini biochimiche e cliniche su due nuovi casi italiani di eterozigosi per l'Hb G-Ferrara.

A. Guerrasio; G. Saglio; C. Camaschella; P. G. Pich; E. Barberis; D. Del Ponte; P. Izzo

Indagini biochimiche e cliniche su due nuovi casi italiani di eterozigosi per l'Hb G-Ferrara.

Translated title of the contribution: Biochemical and clinical studies of 2 new Italian cases of Hb G-Ferrara heterozygosis

A. Guerrasio, G. Saglio, C. Camaschella, P. G. Pich, E. Barberis, D. Del Ponte, P. Izzo

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The Authors report the data concerning a family coming from Ficarolo (Rovigo). The father and one son were found hematologically healthy, but resulted carriers of Hb G-Ferrara. This is an unstable rare pigment with a replacement in the beta 57 (E-1) helicoidal position. The type and site of the mutation explain the "in vitro" molecular instability; on the other hand, this latter doesn't seem to cause any hematological disorder, even if an increased met-Hb production was found when affected blood was incubated at 37 degrees C for two hours in sterile conditions.

Translated title of the contribution	Biochemical and clinical studies of 2 new Italian cases of Hb G-Ferrara heterozygosis
Original language	Italian
Pages (from-to)	967-973
Number of pages	7
Journal	Bollettino della Societa Italiana di Biologia Sperimentale
Volume	55
Issue number	10
Publication status	Published - May 30 1979

ASJC Scopus subject areas

Medicine(all)

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abstract = "The Authors report the data concerning a family coming from Ficarolo (Rovigo). The father and one son were found hematologically healthy, but resulted carriers of Hb G-Ferrara. This is an unstable rare pigment with a replacement in the beta 57 (E-1) helicoidal position. The type and site of the mutation explain the {"}in vitro{"} molecular instability; on the other hand, this latter doesn't seem to cause any hematological disorder, even if an increased met-Hb production was found when affected blood was incubated at 37 degrees C for two hours in sterile conditions.",

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T1 - Indagini biochimiche e cliniche su due nuovi casi italiani di eterozigosi per l'Hb G-Ferrara.

AU - Guerrasio, A.

AU - Saglio, G.

AU - Camaschella, C.

AU - Pich, P. G.

AU - Barberis, E.

AU - Del Ponte, D.

AU - Izzo, P.

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N2 - The Authors report the data concerning a family coming from Ficarolo (Rovigo). The father and one son were found hematologically healthy, but resulted carriers of Hb G-Ferrara. This is an unstable rare pigment with a replacement in the beta 57 (E-1) helicoidal position. The type and site of the mutation explain the "in vitro" molecular instability; on the other hand, this latter doesn't seem to cause any hematological disorder, even if an increased met-Hb production was found when affected blood was incubated at 37 degrees C for two hours in sterile conditions.

AB - The Authors report the data concerning a family coming from Ficarolo (Rovigo). The father and one son were found hematologically healthy, but resulted carriers of Hb G-Ferrara. This is an unstable rare pigment with a replacement in the beta 57 (E-1) helicoidal position. The type and site of the mutation explain the "in vitro" molecular instability; on the other hand, this latter doesn't seem to cause any hematological disorder, even if an increased met-Hb production was found when affected blood was incubated at 37 degrees C for two hours in sterile conditions.

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Indagini biochimiche e cliniche su due nuovi casi italiani di eterozigosi per l'Hb G-Ferrara.

Abstract

ASJC Scopus subject areas

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