Abstract
The Authors report the data concerning a family coming from Ficarolo (Rovigo). The father and one son were found hematologically healthy, but resulted carriers of Hb G-Ferrara. This is an unstable rare pigment with a replacement in the beta 57 (E-1) helicoidal position. The type and site of the mutation explain the "in vitro" molecular instability; on the other hand, this latter doesn't seem to cause any hematological disorder, even if an increased met-Hb production was found when affected blood was incubated at 37 degrees C for two hours in sterile conditions.
| Translated title of the contribution | Biochemical and clinical studies of 2 new Italian cases of Hb G-Ferrara heterozygosis |
|---|---|
| Original language | Italian |
| Pages (from-to) | 967-973 |
| Number of pages | 7 |
| Journal | Bollettino della Societa Italiana di Biologia Sperimentale |
| Volume | 55 |
| Issue number | 10 |
| Publication status | Published - May 30 1979 |
ASJC Scopus subject areas
- Medicine(all)
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Guerrasio, A., Saglio, G., Camaschella, C., Pich, P. G., Barberis, E., Del Ponte, D., & Izzo, P. (1979). Indagini biochimiche e cliniche su due nuovi casi italiani di eterozigosi per l'Hb G-Ferrara. Bollettino della Societa Italiana di Biologia Sperimentale, 55(10), 967-973.