Abstract
The Authors report the data concerning a family coming from Ficarolo (Rovigo). The father and one son were found hematologically healthy, but resulted carriers of Hb G-Ferrara. This is an unstable rare pigment with a replacement in the beta 57 (E-1) helicoidal position. The type and site of the mutation explain the "in vitro" molecular instability; on the other hand, this latter doesn't seem to cause any hematological disorder, even if an increased met-Hb production was found when affected blood was incubated at 37 degrees C for two hours in sterile conditions.
Translated title of the contribution | Biochemical and clinical studies of 2 new Italian cases of Hb G-Ferrara heterozygosis |
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Original language | Italian |
Pages (from-to) | 967-973 |
Number of pages | 7 |
Journal | Bollettino della Societa Italiana di Biologia Sperimentale |
Volume | 55 |
Issue number | 10 |
Publication status | Published - May 30 1979 |
ASJC Scopus subject areas
- Medicine(all)