Biochemical and functional markers of lung damage after bleomycin treatment

F. Villani, M. Galimberti, A. Barbieri, M. Luisetti, L. Bacchella, C. Aprile

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Lung function tests, including spirometry, and pulmonary transfer factor for carbon monoxide (TLCO), serum angiotensin-converting enzyme (sACE), serum copper (sCu ++) and serum procollagen III peptide (sPIIIP) were measured in 20 patients with metastatic testicular carcinoma, before and after treatment with cisplatin, bleomycin, vinblastine or etoposide. A significant decrease of TLCO, total lung capacity and vital capacity was observed at the end of the treatment. No recovery of pulmonary function had taken place 2 yrs after the last dose of bleomycin. This result suggests that bleomycin-induced lung damage is not completely reversible. Serum angiotensin-converting enzyme, remained unmodified, whilst sPIIIP was found to be significantly increased at the end of chemotherapy, but normal 2 yrs after the completion of chemotherapy. Serum Cu ++ showed a tendency to decline. No significant correlation was found between sACE, sCu ++ and sPIIIP and lung function tests in the follow-up period. These results question the possibility that these markers could be useful indicators of bleomycin-induced lung damage.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalMonaldi Archives for Chest Disease - Cardiac Series
Volume50
Issue number3
Publication statusPublished - 1995

Fingerprint

Bleomycin
Biomarkers
Lung
Serum
Procollagen
Peptidyl-Dipeptidase A
Respiratory Function Tests
Therapeutics
Peptides
Total Lung Capacity
Transfer Factor
Drug Therapy
Vinblastine
Spirometry
Recovery of Function
Vital Capacity
Etoposide
Carbon Monoxide
Cisplatin
Copper

Keywords

  • Angiotensin-converting enzyme
  • Bleomycin
  • Copper
  • Lung toxicity
  • Procollagen amino peptide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine

Cite this

Villani, F., Galimberti, M., Barbieri, A., Luisetti, M., Bacchella, L., & Aprile, C. (1995). Biochemical and functional markers of lung damage after bleomycin treatment. Monaldi Archives for Chest Disease - Cardiac Series, 50(3), 183-186.

Biochemical and functional markers of lung damage after bleomycin treatment. / Villani, F.; Galimberti, M.; Barbieri, A.; Luisetti, M.; Bacchella, L.; Aprile, C.

In: Monaldi Archives for Chest Disease - Cardiac Series, Vol. 50, No. 3, 1995, p. 183-186.

Research output: Contribution to journalArticle

Villani, F, Galimberti, M, Barbieri, A, Luisetti, M, Bacchella, L & Aprile, C 1995, 'Biochemical and functional markers of lung damage after bleomycin treatment', Monaldi Archives for Chest Disease - Cardiac Series, vol. 50, no. 3, pp. 183-186.
Villani F, Galimberti M, Barbieri A, Luisetti M, Bacchella L, Aprile C. Biochemical and functional markers of lung damage after bleomycin treatment. Monaldi Archives for Chest Disease - Cardiac Series. 1995;50(3):183-186.
Villani, F. ; Galimberti, M. ; Barbieri, A. ; Luisetti, M. ; Bacchella, L. ; Aprile, C. / Biochemical and functional markers of lung damage after bleomycin treatment. In: Monaldi Archives for Chest Disease - Cardiac Series. 1995 ; Vol. 50, No. 3. pp. 183-186.
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