Biochemical and morphological investigations on nervous tissue of rats inhaling carbon disulphide

M. Maroni, A. Colombi, E. Rota, C. Antonini, O. Picchi, V. Foà, L. Caimi, G. Tettamanti, P. Castano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Despite the great number of clinical and experimental studies on carbon disulphide neuropathy, the mechanism whereby CS 2 produces neurotoxic lesions is far from being entirely understood. Several hypotheses have been suggested to explain the neurotoxic action of CS 2, such as direct enzymatic inhibition, toxic effect of its metabolities and chelation of oligoelements. This paper reports the results of an inhalation experiment on rats exposed to 700 ppm CS 2 5hrs/day, 5 days/week for 12 weeks. In the morphologic study on peripheral nervous structures, the first and most pronounced alterations observed were axonal swelling, marked increase in neurofilaments and disappearance of neurotubules, with no alteration of myelin sheaths. In the biochemical study on brain synaptosomal fractions, a slight decrease in 5'-nucleotidase (E.C. 3.1.3.5.) and particularly a significant decrease in ATPase (Na +-K + dependent) (E.C. 3.6.1.3.)activity were observed. These results seem to suggest that carbon disulphide induces primary axonal lesions, like those observed with other neurotoxic substances such as methyl-n-buthylketone and acrylamide. Together with axoplasmic flow derangement, the axonal membrane energetic impairment might be one of the most promising hypothesis to explain the development of the 'dying back' neuropathies.

Original languageEnglish
Pages (from-to)443-451
Number of pages9
JournalMedicina del Lavoro
Volume70
Issue number6
Publication statusPublished - 1979

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Carbon Disulfide
Nerve Tissue
Inhalation
5'-Nucleotidase
Axonal Transport
Intermediate Filaments
Acrylamide
Poisons
Myelin Sheath
Membranes
Brain
sodium-translocating ATPase
Clinical Studies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Maroni, M., Colombi, A., Rota, E., Antonini, C., Picchi, O., Foà, V., ... Castano, P. (1979). Biochemical and morphological investigations on nervous tissue of rats inhaling carbon disulphide. Medicina del Lavoro, 70(6), 443-451.

Biochemical and morphological investigations on nervous tissue of rats inhaling carbon disulphide. / Maroni, M.; Colombi, A.; Rota, E.; Antonini, C.; Picchi, O.; Foà, V.; Caimi, L.; Tettamanti, G.; Castano, P.

In: Medicina del Lavoro, Vol. 70, No. 6, 1979, p. 443-451.

Research output: Contribution to journalArticle

Maroni, M, Colombi, A, Rota, E, Antonini, C, Picchi, O, Foà, V, Caimi, L, Tettamanti, G & Castano, P 1979, 'Biochemical and morphological investigations on nervous tissue of rats inhaling carbon disulphide', Medicina del Lavoro, vol. 70, no. 6, pp. 443-451.
Maroni M, Colombi A, Rota E, Antonini C, Picchi O, Foà V et al. Biochemical and morphological investigations on nervous tissue of rats inhaling carbon disulphide. Medicina del Lavoro. 1979;70(6):443-451.
Maroni, M. ; Colombi, A. ; Rota, E. ; Antonini, C. ; Picchi, O. ; Foà, V. ; Caimi, L. ; Tettamanti, G. ; Castano, P. / Biochemical and morphological investigations on nervous tissue of rats inhaling carbon disulphide. In: Medicina del Lavoro. 1979 ; Vol. 70, No. 6. pp. 443-451.
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