Biochemical and Pathophysiological Premises to Positron Emission Tomography With Choline Radiotracers

Vincenzo Cuccurullo, Giuseppe Danilo Di Stasio, Laura Evangelista, Gabriella Castoria, Luigi Mansi

Research output: Contribution to journalArticle

Abstract

Choline is a quaternary ammonium base that represents an essential component of phospholipids and cell membranes. Malignant transformation is associated with an abnormal choline metabolism at a higher levels with respect to those exclusively due to cell multiplication. The use of Positron Emission Tomography/Computed Tomography (PET/CT) with radiocholine (RCH), labeled with 11C or 18F, is widely diffuse in oncology, with main reference to restaging of patients with prostate cancer. The enhanced concentration in neoplasm is based not only on the increasing growing rate, but also on more specific issues, such as the augmented uptake in malignant cells due to the up-regulation of choline kinase. Furthermore the role of hypoxia in decreasing choline's uptake determine an in vivo concentration only in well oxygenated tumors, with a lower uptake when malignancy increases, that is, in tumors positive at 18F-Fluoro-deoxyglucose. In this paper we have analyzed the most important issues related to the possible utilization of RCH in diagnostic imaging of human cancer. J. Cell. Physiol. 232: 270–275, 2017.

Original languageEnglish
Pages (from-to)270-275
Number of pages6
JournalJournal of Cellular Physiology
Volume232
Issue number2
Early online dateJul 18 2016
DOIs
Publication statusPublished - Feb 1 2017

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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