Biochemical and pharmacological studies on amineptine (S 1694) and (+)-amphetamine in the rat

R. Samanin, A. Jori, S. Bernasconi, E. Morpugo, S. Garattini

Research output: Contribution to journalArticle

Abstract

The pharmacological activities of amineptine (S 1694) and (+)-amphetamine and their interaction with biogenic amines have been examined in rats. The locomotor activity, stereotyped behaviour and hypothermia induced by amineptine were similar to but not as marked as those produced by (+)-amphetamine, and there was little or no anorectic action. Amineptine does not modify the concentrations of brain noradrenaline or no acetylcholine which are respectively reduced and increased by (+)-amphetamine. Moreover, amineptine does not affect significantly the decrease of brain noradrenaline induced by an intraventricular injection of 6-hydroxydopamine, an effect significantly antagonized by (+)-amphetamine. On the other hand, like amphetamine, amineptine significantly reduces the effect of homovanillic acid and show a cross tolerance in this action. Therefore they could act similarly on the striatal dopaminergic system. Amineptine thus appears to be a new type of antidepressant with a brain biochemical profile differing from that of other drugs used in depressive disorders.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Volume29
Issue number9
Publication statusPublished - 1977

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amineptin
Amphetamine
Pharmacology
Norepinephrine
Brain
Intraventricular Injections
Stereotyped Behavior
Corpus Striatum
Induced Hypothermia
Appetite Depressants
Homovanillic Acid
Biogenic Amines
Oxidopamine
Locomotion
Depressive Disorder
Antidepressive Agents
Acetylcholine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Biochemical and pharmacological studies on amineptine (S 1694) and (+)-amphetamine in the rat. / Samanin, R.; Jori, A.; Bernasconi, S.; Morpugo, E.; Garattini, S.

In: Journal of Pharmacy and Pharmacology, Vol. 29, No. 9, 1977, p. 555-558.

Research output: Contribution to journalArticle

Samanin, R. ; Jori, A. ; Bernasconi, S. ; Morpugo, E. ; Garattini, S. / Biochemical and pharmacological studies on amineptine (S 1694) and (+)-amphetamine in the rat. In: Journal of Pharmacy and Pharmacology. 1977 ; Vol. 29, No. 9. pp. 555-558.
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