Abstract
The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements.
| Original language | English |
|---|---|
| Pages (from-to) | 379-385 |
| Number of pages | 7 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 83 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1986 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter. / Romano, M.; Esteve, A.; Coccia, P.; Masturzo, P.; Galliani, G.; Ghezzi, P.; Salmona, M.
In: Toxicology and Applied Pharmacology, Vol. 83, No. 2, 1986, p. 379-385.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter
AU - Romano, M.
AU - Esteve, A.
AU - Coccia, P.
AU - Masturzo, P.
AU - Galliani, G.
AU - Ghezzi, P.
AU - Salmona, M.
PY - 1986
Y1 - 1986
N2 - The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements.
AB - The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements.
UR - http://www.scopus.com/inward/record.url?scp=0022472042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022472042&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(86)90314-5
DO - 10.1016/0041-008X(86)90314-5
M3 - Article
C2 - 3485839
AN - SCOPUS:0022472042
VL - 83
SP - 379
EP - 385
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 2
ER -