Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter

M. Romano, A. Esteve, P. Coccia, P. Masturzo, G. Galliani, P. Ghezzi, M. Salmona

Research output: Contribution to journalArticle

Abstract

The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalToxicology and Applied Pharmacology
Volume83
Issue number2
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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