Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter

M. Romano, A. Esteve, P. Coccia, P. Masturzo, G. Galliani, P. Ghezzi, M. Salmona

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalToxicology and Applied Pharmacology
Volume83
Issue number2
DOIs
Publication statusPublished - 1986

Fingerprint

Liver Neoplasms
Rats
Liver
7-Alkoxycoumarin O-Dealkylase
Epoxide Hydrolases
Membrane Fluidity
Fluorescence Polarization
Ornithine Decarboxylase
Fluidity
Phenobarbital
Cytochrome P-450 Enzyme System
1,4-bis(2-(3,5-dichloropyridyloxy))benzene
Fluorescence
Polarization
Membranes
DNA
Enzymes

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter. / Romano, M.; Esteve, A.; Coccia, P.; Masturzo, P.; Galliani, G.; Ghezzi, P.; Salmona, M.

In: Toxicology and Applied Pharmacology, Vol. 83, No. 2, 1986, p. 379-385.

Research output: Contribution to journalArticle

@article{b53d4e891bc74ea2a94c246b44dd3ed9,
title = "Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter",
abstract = "The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements.",
author = "M. Romano and A. Esteve and P. Coccia and P. Masturzo and G. Galliani and P. Ghezzi and M. Salmona",
year = "1986",
doi = "10.1016/0041-008X(86)90314-5",
language = "English",
volume = "83",
pages = "379--385",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter

AU - Romano, M.

AU - Esteve, A.

AU - Coccia, P.

AU - Masturzo, P.

AU - Galliani, G.

AU - Ghezzi, P.

AU - Salmona, M.

PY - 1986

Y1 - 1986

N2 - The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements.

AB - The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements.

UR - http://www.scopus.com/inward/record.url?scp=0022472042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022472042&partnerID=8YFLogxK

U2 - 10.1016/0041-008X(86)90314-5

DO - 10.1016/0041-008X(86)90314-5

M3 - Article

C2 - 3485839

AN - SCOPUS:0022472042

VL - 83

SP - 379

EP - 385

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 2

ER -