TY - JOUR
T1 - Biochemical characterization of VIM-39, a VIM-1-like metallo-β-lactamase variant from a multidrug-resistant Klebsiella pneumoniae isolate from Greece
AU - Papagiannitsis, Costas C.
AU - Pollini, Simona
AU - De Luca, Filomena
AU - Rossolini, Gian Maria
AU - Docquier, Jean Denis
AU - Hrabák, Jaroslav
PY - 2015/12/1
Y1 - 2015/12/1
N2 - VIM-39, a VIM-1-like metallo-β-lactamase variant (VIM-1 Thr33Ala His224Leu) was identified in a clinical isolate of Klebsiella pneumoniae belonging to sequence type 147. VIM-39 hydrolyzed ampicillin, cephalothin, and imipenem more efficiently than did VIM-1 and VIM-26 (a VIM-1 variant with the His224Leu substitution) because of higher turnover rates.
AB - VIM-39, a VIM-1-like metallo-β-lactamase variant (VIM-1 Thr33Ala His224Leu) was identified in a clinical isolate of Klebsiella pneumoniae belonging to sequence type 147. VIM-39 hydrolyzed ampicillin, cephalothin, and imipenem more efficiently than did VIM-1 and VIM-26 (a VIM-1 variant with the His224Leu substitution) because of higher turnover rates.
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U2 - 10.1128/AAC.01935-15
DO - 10.1128/AAC.01935-15
M3 - Article
AN - SCOPUS:84954531242
VL - 59
SP - 7811
EP - 7814
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 12
ER -