Biochemical characterization of VIM-39, a VIM-1-like metallo-β-lactamase variant from a multidrug-resistant Klebsiella pneumoniae isolate from Greece

Costas C. Papagiannitsis; Simona Pollini; Filomena De Luca; Gian Maria Rossolini; Jean Denis Docquier; Jaroslav Hrabák

doi:10.1128/AAC.01935-15

Biochemical characterization of VIM-39, a VIM-1-like metallo-β-lactamase variant from a multidrug-resistant Klebsiella pneumoniae isolate from Greece

Costas C. Papagiannitsis, Simona Pollini, Filomena De Luca, Gian Maria Rossolini, Jean Denis Docquier, Jaroslav Hrabák

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

VIM-39, a VIM-1-like metallo-β-lactamase variant (VIM-1 Thr33Ala His224Leu) was identified in a clinical isolate of Klebsiella pneumoniae belonging to sequence type 147. VIM-39 hydrolyzed ampicillin, cephalothin, and imipenem more efficiently than did VIM-1 and VIM-26 (a VIM-1 variant with the His224Leu substitution) because of higher turnover rates.

Original language	English
Pages (from-to)	7811-7814
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01935-15
Publication status	Published - Dec 1 2015

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology
Infectious Diseases

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Biochemical characterization of VIM-39, a VIM-1-like metallo-β-lactamase variant from a multidrug-resistant Klebsiella pneumoniae isolate from Greece. / Papagiannitsis, Costas C.; Pollini, Simona; De Luca, Filomena; Rossolini, Gian Maria; Docquier, Jean Denis; Hrabák, Jaroslav.

In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 12, 01.12.2015, p. 7811-7814.

Research output: Contribution to journal › Article › peer-review

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abstract = "VIM-39, a VIM-1-like metallo-β-lactamase variant (VIM-1 Thr33Ala His224Leu) was identified in a clinical isolate of Klebsiella pneumoniae belonging to sequence type 147. VIM-39 hydrolyzed ampicillin, cephalothin, and imipenem more efficiently than did VIM-1 and VIM-26 (a VIM-1 variant with the His224Leu substitution) because of higher turnover rates.",

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AU - Rossolini, Gian Maria

AU - Docquier, Jean Denis

AU - Hrabák, Jaroslav

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