A significantly low level of i-PTH values was seen in thalassemic patients (when matched with normal control of the same age). One patient, 15 yr old, showed the biochemical picture of parathyroid insufficiency. Seven patients (58%) had normal serum calcium with significantly low i-PTH values. The authors' data are in accordance with the reports of Flynn and coworkers (normal calcium, low i-PTH values) and are characteristic of the biochemical and clinical picture described as 'Phosphate depletion syndrome'. In thalassemic patients the authors found a significantly high value of TRP and TmPO4/GFR and, on the other hand, the literature reports a normal intestinal absorption in thalassemic patients. The authors can suppose an interrelationship between phosphate deficiency and a periodic event in the thalassemic patient's life (e.g., transfusion therapy) that can produce a loss of phosphate in the urine.
|Translated title of the contribution||Biochemical data in the phosphate depletion syndrome of thalassemic patient|
|Number of pages||7|
|Journal||Pediatria Medica e Chirurgica|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health